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Kapp JA, Pierce CW, Theze J, et al. Modulation of immune responses by suppressor T cells. Fed Proc. 1978;37(10):2361-64
Kapp, J. A., Pierce, C. W., Theze, J., & Benacerraf, B. (1978). Modulation of immune responses by suppressor T cells. Federation proceedings, 37(10), 2361-64.
Kapp, J A, et al. "Modulation of immune responses by suppressor T cells." Federation proceedings vol. 37,10 (1978): 2361-64.
Kapp JA, Pierce CW, Theze J, Benacerraf B. Modulation of immune responses by suppressor T cells. Fed Proc. 1978 Aug;37(10):2361-64. PMID: 79503.
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Fed Proc. 1978 Aug;37(10):2361-64.

Modulation of immune responses by suppressor T cells.

Federation proceedings

J A Kapp, C W Pierce, J Theze, B Benacerraf

PMID: 79503

Abstract

The activity of suppressor T cells has been demonstrated in almost every phase of the immune response. These regulatory cells modulate both humoral and cell-mediated immunity utilizing antigen-specific and nonspecific mechanisms. For comparative purposes two murine models are described, the nonspecific suppressor T cell stimulated by the mitogen concanavalin A and the antigen-specific suppressor T cell stimulated by injection of the synthetic terpolymer acid 60-L-alanine30-L-tyrosine10 (GAT) in nonresponder mice. These two T cells are similar to expression of Ly alloantigens, ability to inhibit antibody responses, and the mediation of suppression, at least in part, by soluble products. However, differences in radio-resistance and antigenic specificity of the suppressor T cells, as well as differences in molecular characteristics of the soluble factors and their targets suggest that these T cells regulate the immune response by different mechanisms. The relationship of these two suppressor T cells to other nonspecific and antigen-specific suppressor T cells is discussed.

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