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Miyata M, Kogure A, Sato H, et al. Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase. Clin Rheumatol. 1995;14(6):673-7doi: 10.1007/BF02207935.
Miyata, M., Kogure, A., Sato, H., Kodama, E., Watanabe, H., Ohira, H., Kuroda, M., Takagi, T., Sato, Y., & Kasukawa, R. (1995). Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase. Clinical rheumatology, 14(6), 673-7. https://doi.org/10.1007/BF02207935
Miyata, M, et al. "Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase." Clinical rheumatology vol. 14,6 (1995): 673-7. doi: https://doi.org/10.1007/BF02207935
Miyata M, Kogure A, Sato H, Kodama E, Watanabe H, Ohira H, Kuroda M, Takagi T, Sato Y, Kasukawa R. Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase. Clin Rheumatol. 1995 Nov;14(6):673-7. doi: 10.1007/BF02207935. PMID: 8608687.
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Clin Rheumatol. 1995 Nov;14(6):673-7. doi: 10.1007/BF02207935.

Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase.

Clinical rheumatology

M Miyata, A Kogure, H Sato, E Kodama, H Watanabe, H Ohira, M Kuroda, T Takagi, Y Sato, R Kasukawa

Affiliations

  1. Department of Internal Medicine II, Fukushima Medical College, JAPAN.

PMID: 8608687 DOI: 10.1007/BF02207935

Abstract

The antibody to 65 KD mycobacterial heat shock protein (HSP65) and antibody to human superoxide dismutase (H-SOD) were measured by ELISA in patients with autoimmune hepatitis (AIH), and results were compared with those of patients with chronic active hepatitis C (CAH-C) or systemic lupus erythematosus (SLE) and normal subjects (NS). Patients with AIH had significantly higher OD values of anti-HSP65 antibody and anti-H-SOD antibody compared with those of patients with CAH-C or SLE and NS. OD values of anti-HSP65 antibody were correlated with those of anti-SOD antibody. Affinity-purified anti-SOD antibody reacted with HSP65. Analysis of the amino acid sequence of human SOD showed that 7 segments, corresponding to r to 25 amino acid residues, exhibited 50 to 71% homology with that of my mycobacterial HSP65.

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