Med Clin (Barc). 1996 Mar 30;106(12):460-2.

[Chronic autoimmune hepatitis following cholestatic hepatitis caused by droxicam].

Medicina clinica

[Article in Spanish]
F Pérez-Aguilar, M Berenguer, J J Ramírez-Palanca, A Payà, F J Vera-Sempere, J M Sánchez-Cuenca, J Berenguer

PMID: 8656732

Abstract

Droxicam in a nonsteroid antiinflammatory from the oxicam family which acts as a pro-drug, being transformed into pyroxicam after being hydrolized in the stomach and has induced several cases of cholestatic or mixed hepatitis. A clinical observation in which droxicam provoked initial cholestatic hepatitis which later developed into chronic autoimmune hepatitis is presented. It has been postulated that, after causing cholestatic hepatitis by hypersensitivity and within the context of a previous autoimmune entity such as vitiligo, this drug triggered a silent autoimmune liver disease which was demonstrated clinical, analytical and histopathological manifestations 18 months later and required permanent immunosuppressive treatment.

Substances

• Anti-Inflammatory Agents, Non-Steroidal
• Immunosuppressive Agents
• Pyridines
• droxicam

MeSH terms

• Aged
• Anti-Inflammatory Agents, Non-Steroidal / adverse effects
• Autoimmune Diseases* / drug therapy
• Chemical and Drug Induced Liver Injury / etiology
• Chemical and Drug Induced Liver Injury / pathology
• Cholestasis / chemically induced
• Cholestasis / pathology
• Chronic Disease
• Follow-Up Studies
• Hepatitis / drug therapy
• Hepatitis / immunology
• Hepatitis / pathology
• Humans
• Immunosuppressive Agents / therapeutic use
• Liver / pathology
• Male
• Pyridines / adverse effects
• Time Factors

Publication Types

• Case Reports
• Journal Article