Display options
Share it on

Eur J Nucl Med. 1995 Nov;22(11):1232-7. doi: 10.1007/BF00801605.

Correlation of the findings of thallium-201 chloride scans with those of other imaging modalities and histology following therapy in patients with bone and soft tissue sarcomas.

European journal of nuclear medicine

L Kostakoglu, D M Panicek, C R Divgi, J Botet, J Healey, S M Larson, H M Abdel-Dayem

Affiliations

  1. Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, USA.

PMID: 8575469 DOI: 10.1007/BF00801605

Abstract

We performed a retrospective [corrected] study to evaluate the imaging potential of thallium-201 as compared with other imaging modalities in differentiating residual/recurrent tumors from post-therapy changes in patients with musculoskeletal sarcomas. 201Tl scans, magnetic resonance imaging (17), X-ray computed tomography (6) or contrast angiography (6) studies in 29 patients previously treated for musculoskeletal sarcomas were correlated with either histopathologic findings (26 patients) or 2-year clinical follow-up (three patients). All imaging studies were acquired within 2 weeks. Ratios of 201Tl tumor uptake to the contralateral (28 patients) or adjacent region of interest were calculated. When qualitative interpretation was in doubt, only those cases with a ratio of 1.5 or more were considered suggestive of recurrent of residual viable tumor tissue. Residual or recurrent tumor tissue was verified in 21 patients by biopsy. All had true-positive 201Tl scans while the other imaging modalities were true-positive in 20 and equivocal in one. In eight patients, there was no evidence of viable tumor tissue as proven by biopsy in five and long-term clinical follow-up in three. 201Tl scan was false-positive (ratio 1.5) in one patient and true-negative in seven while the other imaging modalities had four false-positives. The average 201Tl ratios were 2.8+/-1.1 in the true-positive cases and 1.3+/-0.3 in the true-negative cases. The percentage sensitivities, specificities, and accuracy for 201Tl were 100%, 87.5%, and 96.5% versus 95%, 50%, and 82.7% respectively for other imaging modalities. These results indicate that 201Tl scintigraphy is more accurate than other imaging modalities in differentiating residual/recurrent musculoskeletal sarcomas from post-therapy changes.

References

  1. Nucl Med Commun. 1989 Jul;10 (7):477-85 - PubMed
  2. AJR Am J Roentgenol. 1990 Aug;155(2):343-6 - PubMed
  3. J Nucl Med Allied Sci. 1979 Oct-Dec;23(4):163-6 - PubMed
  4. J Comput Assist Tomogr. 1990 Jan-Feb;14(1):1-10 - PubMed
  5. AJR Am J Roentgenol. 1990 Apr;154(4):763-9 - PubMed
  6. AJR Am J Roentgenol. 1991 Oct;157(4):825-33 - PubMed
  7. J Nucl Med. 1991 Aug;32(8):1508-12 - PubMed
  8. AJR Am J Roentgenol. 1986 Apr;146(4):749-56 - PubMed
  9. AJR Am J Roentgenol. 1989 Sep;153(3):541-7 - PubMed
  10. Radiology. 1992 Jan;182(1):185-94 - PubMed
  11. J Nucl Med. 1992 Mar;33(3):319-24 - PubMed
  12. AJR Am J Roentgenol. 1991 Aug;157(2):347-51 - PubMed
  13. J Nucl Med. 1988 Feb;29(2):181-6 - PubMed
  14. Eur J Nucl Med. 1988;13(10 ):527-9 - PubMed
  15. J Nucl Med. 1990 May;31(5):567-72 - PubMed
  16. AJR Am J Roentgenol. 1991 Aug;157(2):353-8 - PubMed
  17. Radiology. 1992 Jul;184(1):243-8 - PubMed
  18. Radiology. 1986 Jul;160(1):125-33 - PubMed
  19. Radiology. 1990 Mar;174(3 Pt 1):847-53 - PubMed
  20. Radiol Med. 1992 Jul-Aug;84(1-2):15-21 - PubMed
  21. Skeletal Radiol. 1985;13(2):134-46 - PubMed

Substances

MeSH terms

Publication Types