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Sebag J, Reed WP, Williams RC. Effect of temperature on bacterial killing by serum and by polymorphonuclear leukocytes. Infect Immun. 1977;16(3):947-54doi: 10.1128/iai.16.3.947-954.1977.
Sebag, J., Reed, W. P., & Williams, R. C. (1977). Effect of temperature on bacterial killing by serum and by polymorphonuclear leukocytes. Infection and immunity, 16(3), 947-54. https://doi.org/10.1128/iai.16.3.947-954.1977
Sebag, J, et al. "Effect of temperature on bacterial killing by serum and by polymorphonuclear leukocytes." Infection and immunity vol. 16,3 (1977): 947-54. doi: https://doi.org/10.1128/iai.16.3.947-954.1977
Sebag J, Reed WP, Williams RC. Effect of temperature on bacterial killing by serum and by polymorphonuclear leukocytes. Infect Immun. 1977 Jun;16(3):947-54. doi: 10.1128/iai.16.3.947-954.1977. PMID: 19356; PMCID: PMC421056.
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Infect Immun. 1977 Jun;16(3):947-54. doi: 10.1128/iai.16.3.947-954.1977.

Effect of temperature on bacterial killing by serum and by polymorphonuclear leukocytes.

Infection and immunity

J Sebag, W P Reed, R C Williams

PMID: 19356 PMCID: PMC421056 DOI: 10.1128/iai.16.3.947-954.1977
Free PMC Article

Abstract

Bacterial killing by serum alone and by polymorphonuclear )PMN) leukocytes was studied at 37 degrees C and compared with killing at 39 and 41 degrees C. The test organisms for serum killing were Staphylococcus aureus 502A (serum resistant) and Escherichia coli O14 (serum sensitive). The organisms used in PMN killing tests were Streptococcus pneumoniae type 29 and E. coli O86.S aureus was not killed by serum alone at any temperature. Changes in temperature did not affect the rate of serum killing of E. coli O14 for the first 60 min, but by 90 and 120 min there was a discrepancy with continued killing at 37 degrees C, but no further killing at 39 and 41 degrees C. PMN phagocytic killing of the pneumococcus was enhanced at 39 degrees C compared with 37 degrees C, and phagocytic killing of E. coli O86 was decreased at 41 degrees C when compared with 37 degrees C. Therefore, it appears that under certain circumstances fever may aid the host PMNs in destroying organisms, whereas under other circumstances it may interfere with such destruction.

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