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Rotter JI, Rimoin DL. Peptic ulcer disease--a heterogeneous group of disorders?. Gastroenterology. 1977;73(3):604-7
Rotter, J. I., & Rimoin, D. L. (1977). Peptic ulcer disease--a heterogeneous group of disorders?. Gastroenterology, 73(3), 604-7.
Rotter, J I, and Rimoin, D L. "Peptic ulcer disease--a heterogeneous group of disorders?." Gastroenterology vol. 73,3 (1977): 604-7.
Rotter JI, Rimoin DL. Peptic ulcer disease--a heterogeneous group of disorders?. Gastroenterology. 1977 Sep;73(3):604-7. PMID: 19337.
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Elsevier Science

Gastroenterology. 1977 Sep;73(3):604-7.

Peptic ulcer disease--a heterogeneous group of disorders?.

Gastroenterology

J I Rotter, D L Rimoin

PMID: 19337

Abstract

The familial aggregation of peptic ulcer disease has been well established, as has its association with such clear-cut genetic factors as blood group O and nonsecretor status. However, the genetics of this disorder, or group of disorders, is still in question. Polygenic inheritance is the prevailing hypothesis that has been proposed for peptic ulcer. This hypothesis was based primarily on the exclusion of a simple mode of inheritance for all ulcer disease. Genetic heterogeneity is an alternative hypothesis that can explain both the familial aggregation of peptic ulcer disease and the lack of a simple Mendelian pattern of inheritance. The evidence for genetic heterogeneity in peptic ulcer disease is reviewed, and studies are proposed to test this hypothesis.

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