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Shepherd AM, Hewick DS, Moreland TA, et al. Age as a determinant of sensitivity to warfarin. Br J Clin Pharmacol. 1977;4(3):315-20doi: 10.1111/j.1365-2125.1977.tb00719.x.
Shepherd, A. M., Hewick, D. S., Moreland, T. A., & Stevenson, I. H. (1977). Age as a determinant of sensitivity to warfarin. British journal of clinical pharmacology, 4(3), 315-20. https://doi.org/10.1111/j.1365-2125.1977.tb00719.x
Shepherd, A M, et al. "Age as a determinant of sensitivity to warfarin." British journal of clinical pharmacology vol. 4,3 (1977): 315-20. doi: https://doi.org/10.1111/j.1365-2125.1977.tb00719.x
Shepherd AM, Hewick DS, Moreland TA, Stevenson IH. Age as a determinant of sensitivity to warfarin. Br J Clin Pharmacol. 1977 Jun;4(3):315-20. doi: 10.1111/j.1365-2125.1977.tb00719.x. PMID: 901699; PMCID: PMC1429084.
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Br J Clin Pharmacol. 1977 Jun;4(3):315-20. doi: 10.1111/j.1365-2125.1977.tb00719.x.

Age as a determinant of sensitivity to warfarin.

British journal of clinical pharmacology

A M Shepherd, D S Hewick, T A Moreland, I H Stevenson

PMID: 901699 PMCID: PMC1429084 DOI: 10.1111/j.1365-2125.1977.tb00719.x
Free PMC Article

Abstract

1 Parallel human and rat studies were carried out to confirm the previous suggestion of an increased sensitivity to warfarin in old age. 2 The anticoagulant response to warfarin was found to be greater in the elderly groups despite, in the case of the patient study, the elderly subjects being given a smaller weight-related dose. 3 At the same plasma warfarin concentrations there was greater inhibition of vitamin K-dependent clotting factor synthesis in the elderly. There was no difference in the rate of clotting factor degradation in the two age groups. 4 There was no appreciable difference in warfarin pharmacokinetics (plasma half-life, apparent volume of distribution, plasma clearance, plasma protein binding or plasma warfarin alcohol levels) in the two age groups. 5 There appeared to be no major age-related differences in warfarin pharmacokinetics and the increased effect of warfarin in the elderly seemed to result from an increased intrinsic sensitivity to warfarin.

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