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Loupart ML, Walker R, Brammar W, et al. Confirmation of the copy number of chromosome 1 in interphase nuclei from paraffin sections of breast tumours by fluorescence in situ hybridization. Chromosome Res. 1995;3(7):410-6doi: 10.1007/BF00713890.
Loupart, M. L., Walker, R., Brammar, W., & Varley, J. (1995). Confirmation of the copy number of chromosome 1 in interphase nuclei from paraffin sections of breast tumours by fluorescence in situ hybridization. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 3(7), 410-6. https://doi.org/10.1007/BF00713890
Loupart, M L, et al. "Confirmation of the copy number of chromosome 1 in interphase nuclei from paraffin sections of breast tumours by fluorescence in situ hybridization." Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology vol. 3,7 (1995): 410-6. doi: https://doi.org/10.1007/BF00713890
Loupart ML, Walker R, Brammar W, Varley J. Confirmation of the copy number of chromosome 1 in interphase nuclei from paraffin sections of breast tumours by fluorescence in situ hybridization. Chromosome Res. 1995 Nov;3(7):410-6. doi: 10.1007/BF00713890. PMID: 8528585.
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Chromosome Res. 1995 Nov;3(7):410-6. doi: 10.1007/BF00713890.

Confirmation of the copy number of chromosome 1 in interphase nuclei from paraffin sections of breast tumours by fluorescence in situ hybridization.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

M L Loupart, R Walker, W Brammar, J Varley

Affiliations

  1. ICI/University Joint Laboratory, University of Leicster, UK.

PMID: 8528585 DOI: 10.1007/BF00713890

Abstract

Fluorescence in situ hybridization (FISH) was used to establish the copy number of chromosome 1 in a set of nine breast tumours in which the chromosome had previously been shown to have undergone a variety of rearrangements by loss of heterozygosity studies. In each case, FISH with satellite III DNA from chromosome 1q12 confirmed the results obtained by Southern hybridization. Importantly, in all five cases with rearrangements thought not to involve the centromeric region, FISH showed that the events had not disrupted the gross chromosome structure. This study highlights the potential of using the two techniques together to obtain a clearer picture of both large- and small-scale alterations to chromosomes in solid tumours.

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