Cancer. 1993 May 01;71(9):2847-53. doi: 10.1002/1097-0142(19930501)71:9<2847::aid-cncr2820710928>3.0.co;2-e.

Bone tumors other than osteosarcoma after retinoblastoma.

Cancer

K J Helton, B D Fletcher, L E Kun, J J Jenkins, C B Pratt

PMID: 8467462 DOI: 10.1002/1097-0142(19930501)71:9<2847::aid-cncr2820710928>3.0.co;2-e

Abstract

BACKGROUND: The most frequent second malignant neoplasm after retinoblastoma is osteosarcoma, which may be associated with radiation therapy or arise de novo in patients with bilateral retinoblastoma.

METHODS: Clinical, pathologic, and diagnostic imaging findings in two patients with Ewing sarcoma (ES) and one with peripheral neuroepithelioma (PN) are presented.

RESULTS: Second malignant neoplasms located in the extremities or pelvis were seen 12-18 years after initial diagnosis of unilateral (two patients) or bilateral (one patient) retinoblastoma. The patients with unilateral retinoblastoma were treated by enucleation only; the other received ocular radiation therapy and chemotherapy. To the knowledge of the authors, this is the first documentation of round blue cell tumor after unilateral retinoblastoma.

CONCLUSIONS: ES and PN should be included in the differential diagnosis of malignant neoplasms occurring after treatment of unilateral or bilateral retinoblastoma.

MeSH terms

• Adult
• Bone Neoplasms / diagnosis
• Combined Modality Therapy
• Eye Enucleation
• Eye Neoplasms / therapy
• Female
• Humans
• Infant
• Magnetic Resonance Imaging
• Male
• Neoplasms, Second Primary / diagnosis
• Neuroectodermal Tumors, Primitive, Peripheral / diagnosis
• Retinoblastoma / therapy
• Sarcoma, Ewing / diagnosis
• Tomography, X-Ray Computed

Publication Types

• Case Reports
• Journal Article
• Research Support, Non-U.S. Gov't
• Research Support, U.S. Gov't, P.H.S.
• Review

Grant support

• CA21075/CA/NCI NIH HHS/United States
• CA23099/CA/NCI NIH HHS/United States