Display options
Share it on
Full text links
Atypon

Science. 1977 Sep 16;197(4309):1189-91. doi: 10.1126/science.897662.

Competition of delta 9-tetrahydrocannabinol with estrogen in rat uterine estrogen receptor binding.

Science (New York, N.Y.)

A B Rawitch, G S Schultz, K E Ebner, R M Vardaris

PMID: 897662 DOI: 10.1126/science.897662

Abstract

Direct competition experiments with delta 9 -tetrahydrocannibinol (delta 9-THC) and estradiol in binding assays with rat uterine cytosol estrogen receptors showed that delta 9-THC was a weak, but nevertheless significant, competitor for binding to cytoplasmic estrogen receptors. These data support, at the molecular level, the observations that delta 9-THC has a weak estrogenic activity (at least the ability to bind to estrogen receptors). Moreover, estrogen-like binding suggests that delta 9-THC, acting at the level of estrogen receptor, causes a primary estrogenic effect rather than an indirect or secondary phenomenon.

Similar articles

Substances

MeSH terms

Publication Types

LinkOut - more resources