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Cozzi J, Chevret E, Rousseaux S, et al. Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient. Hum Genet. 1994;93(1):32-4doi: 10.1007/BF00218909.
Cozzi, J., Chevret, E., Rousseaux, S., Pelletier, R., Benitz, V., Jalbert, H., & Sèle, B. (1994). Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient. Human genetics, 93(1), 32-4. https://doi.org/10.1007/BF00218909
Cozzi, J, et al. "Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient." Human genetics vol. 93,1 (1994): 32-4. doi: https://doi.org/10.1007/BF00218909
Cozzi J, Chevret E, Rousseaux S, Pelletier R, Benitz V, Jalbert H, Sèle B. Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient. Hum Genet. 1994 Jan;93(1):32-4. doi: 10.1007/BF00218909. PMID: 8270252.
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Hum Genet. 1994 Jan;93(1):32-4. doi: 10.1007/BF00218909.

Achievement of meiosis in XXY germ cells: study of 543 sperm karyotypes from an XY/XXY mosaic patient.

Human genetics

J Cozzi, E Chevret, S Rousseaux, R Pelletier, V Benitz, H Jalbert, B Sèle

Affiliations

  1. Cytogenetic and Reproductive Biology Laboratory, Grenoble University Medical School, France.

PMID: 8270252 DOI: 10.1007/BF00218909

Abstract

Human sperm chromosomes from a 46,XY/47,XXY male were obtained using the technique of in vitro penetration of zona-free hamster eggs. The analysis of 543 sperm complements shows a significantly increased incidence (0.9%) of hyperhaploid gonosomal 24,XY sets, with a lack of the expected corresponding gonosomal hypohaploidies, and a normal rate of autosomal non-disjunctions. These results support the suggestion that 47,XXY cells are able to go through meiosis and to form spermatozoa. Only 24,XY sperm chromosomal constitutions were observed suggesting a preferential pairing of homologous sex chromosomes in 47,XXY spermatocytes.

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