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Drent M, Kuks PF, van den Bosch JM, et al. Psychische klachten door overdosering van theofylline; noodzakelijkheid van spiegelcontrole. [Psychiatric symptoms due to theophylline overdose; the necessity of blood level monitoring]. Ned Tijdschr Geneeskd. 1993;137(36):1831-5
Drent, M., Kuks, P. F., van den Bosch, J. M., & Brandt, K. H. (1993). Psychische klachten door overdosering van theofylline; noodzakelijkheid van spiegelcontrole. [Psychiatric symptoms due to theophylline overdose; the necessity of blood level monitoring]. Nederlands tijdschrift voor geneeskunde, 137(36), 1831-5.
Drent, M, et al. "Psychische klachten door overdosering van theofylline; noodzakelijkheid van spiegelcontrole." [Psychiatric symptoms due to theophylline overdose; the necessity of blood level monitoring]. Nederlands tijdschrift voor geneeskunde vol. 137,36 (1993): 1831-5.
Drent M, Kuks PF, van den Bosch JM, Brandt KH. Psychische klachten door overdosering van theofylline; noodzakelijkheid van spiegelcontrole. [Psychiatric symptoms due to theophylline overdose; the necessity of blood level monitoring]. Ned Tijdschr Geneeskd. 1993 Sep 04;137(36):1831-5. Dutch. PMID: 8377864.
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Ned Tijdschr Geneeskd. 1993 Sep 04;137(36):1831-5.

[Psychiatric symptoms due to theophylline overdose; the necessity of blood level monitoring].

Nederlands tijdschrift voor geneeskunde

[Article in Dutch]
M Drent, P F Kuks, J M van den Bosch, K H Brandt

Affiliations

  1. Afd. Longziekten, St. Antonius Ziekenhuis, Nieuwegein.

PMID: 8377864

Abstract

Two patients presented with severe side effects of theophylline. Due to the theophylline intoxication patient A developed ischaemic hepatitis, which made haemodialysis treatment necessary to accelerate the elimination of the drug from the body. The intoxication caused immobilisation and total dependence with respect to the daily activities of patient B. In neither case was the association between mood disorders--like depression, agitation and anxiety--and an overdose of theophylline recognised. Administration of theophylline should be monitored with regular measurements of the serum theophylline concentration, because of its narrow therapeutic margin and the serious toxic side effects.

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