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Deftos LJ, Burton DW, Brandt DW. Parathyroid hormone-like protein is a secretory product of atrial myocytes. J Clin Invest. 1993;92(2):727-35doi: 10.1172/JCI116643.
Deftos, L. J., Burton, D. W., & Brandt, D. W. (1993). Parathyroid hormone-like protein is a secretory product of atrial myocytes. The Journal of clinical investigation, 92(2), 727-35. https://doi.org/10.1172/JCI116643
Deftos, L J, et al. "Parathyroid hormone-like protein is a secretory product of atrial myocytes." The Journal of clinical investigation vol. 92,2 (1993): 727-35. doi: https://doi.org/10.1172/JCI116643
Deftos LJ, Burton DW, Brandt DW. Parathyroid hormone-like protein is a secretory product of atrial myocytes. J Clin Invest. 1993 Aug;92(2):727-35. doi: 10.1172/JCI116643. PMID: 8349812; PMCID: PMC294907.
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American Society for Clinical Investigation Free PMC Article

J Clin Invest. 1993 Aug;92(2):727-35. doi: 10.1172/JCI116643.

Parathyroid hormone-like protein is a secretory product of atrial myocytes.

The Journal of clinical investigation

L J Deftos, D W Burton, D W Brandt

Affiliations

  1. Department of Medicine, University of California San Diego.

PMID: 8349812 PMCID: PMC294907 DOI: 10.1172/JCI116643
Free PMC Article

Abstract

Parathyroid hormone-like protein (PLP) was originally identified from tumors associated with hypercalcemia. Recently, it has been found to be expressed in a stretch-responsive manner in several types of smooth muscle. We studied adult rat heart muscle for the presence of the PLP. Using immunohistology and the PCR, we demonstrated the presence of PLP and its mRNA in all heart chambers. Immunoelectron microscopy demonstrated PLP in secretory vesicles of atrial mycocytes. Using immunoassay, we demonstrated that atria contained a higher concentration of PLP than ventricles. Furthermore, primary cultures of both chambers released PLP into conditioned medium, with atria secreting more than ventricles. Considered with studies of the role of PLP in other tissues, our observations suggest that the production and secretion of PLP by cardiac myocytes represents a calcium-related regulatory function for this stretch-responsive polypeptide in the cardiovascular system. PLP in the heart may be the calcium counterpart for the atrial natriuretic-sodium regulatory axis of the cardiovascular system.

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