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Du XJ, Dart AM, Riemersma RA. Lack of modulation by dietary unsaturated fats on sympathetic neurotransmission in rat hearts. Am J Physiol. 1993;265(3):H886-92doi: 10.1152/ajpheart.1993.265.3.H886.
Du, X. J., Dart, A. M., & Riemersma, R. A. (1993). Lack of modulation by dietary unsaturated fats on sympathetic neurotransmission in rat hearts. The American journal of physiology, 265(3), H886-92. https://doi.org/10.1152/ajpheart.1993.265.3.H886
Du, X J, et al. "Lack of modulation by dietary unsaturated fats on sympathetic neurotransmission in rat hearts." The American journal of physiology vol. 265,3 (1993): H886-92. doi: https://doi.org/10.1152/ajpheart.1993.265.3.H886
Du XJ, Dart AM, Riemersma RA. Lack of modulation by dietary unsaturated fats on sympathetic neurotransmission in rat hearts. Am J Physiol. 1993 Sep;265(3):H886-92. doi: 10.1152/ajpheart.1993.265.3.H886. PMID: 8214123.
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Am J Physiol. 1993 Sep;265(3):H886-92. doi: 10.1152/ajpheart.1993.265.3.H886.

Lack of modulation by dietary unsaturated fats on sympathetic neurotransmission in rat hearts.

The American journal of physiology

X J Du, A M Dart, R A Riemersma

Affiliations

  1. Department of Medicine (Royal Infirmary of Edinburgh), University of Edinburgh, United Kingdom.

PMID: 8214123 DOI: 10.1152/ajpheart.1993.265.3.H886

Abstract

We examined the effect of dietary polyunsaturated fatty acids (PUFA) on cardiac sympathetic neurotransmission. Rats were fed semisynthetic diets (18.5% fat wt/wt) high in saturated fatty acids (control diet), high in n-6 PUFA (corn oil), or enriched with n-3 PUFA (Maxepa). A perfused innervated heart model was used to examine different aspects of sympathetic neurotransmission 10 wk after the feeding. Dietary PUFA increased the content of n-6 or n-3 PUFA in myocardial phospholipids compared with animals fed control diets. Myocardial norepinephrine content, sympathetic nerve stimulation-induced norepinephrine release, neural reuptake, presynaptic alpha-adrenergic inhibition of norepinephrine release, and postsynaptic inotropic response (+/- dP/dt) to sympathetic nerve stimulation or to a beta-agonist were essentially not influenced by dietary PUFA. Neural norepinephrine release during prolonged ischemia (60 min) was also similar in hearts from rats fed n-6 PUFA and control diets. Thus a modification of sympathetic neurotransmission was not achieved by feeding PUFA-enriched diets for 10 wk.

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