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Infect Dis Clin North Am. 1993 Jun;7(2):411-24.

Problems with detection of beta-lactam resistance among nonfastidious gram-negative bacilli.

Infectious disease clinics of North America

C C Sanders, K S Thomson, P A Bradford

Affiliations

  1. Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska.

PMID: 8345176

Abstract

The single most important aspect of any susceptibility test is the accurate detection of resistance, because resistance carries a strong prediction of therapeutic failure. However, the accurate detection of resistance has been difficult in tests performed with gram-negative organisms producing certain beta-lactamases and in tests with the new beta-lactam drug/beta-lactamase inhibitor combinations. These problems are due to limitations in the design of studies performed to establish test parameters, and these problems can be avoided if a new predictor panel approach is used. This, coupled with the use of special tests to detect resistance mechanisms, could optimize the accurate identification of beta-lactam resistance in gram-negative bacteria.

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