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Granvil CP, Sharkawi M, Plaa GL. Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice. Toxicol Lett. 1994;70(3):263-7doi: 10.1016/0378-4274(94)90120-1.
Granvil, C. P., Sharkawi, M., & Plaa, G. L. (1994). Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice. Toxicology letters, 70(3), 263-7. https://doi.org/10.1016/0378-4274(94)90120-1
Granvil, C P, et al. "Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice." Toxicology letters vol. 70,3 (1994): 263-7. doi: https://doi.org/10.1016/0378-4274(94)90120-1
Granvil CP, Sharkawi M, Plaa GL. Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice. Toxicol Lett. 1994 Feb 15;70(3):263-7. doi: 10.1016/0378-4274(94)90120-1. PMID: 8284793.
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Elsevier Science

Toxicol Lett. 1994 Feb 15;70(3):263-7. doi: 10.1016/0378-4274(94)90120-1.

Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice.

Toxicology letters

C P Granvil, M Sharkawi, G L Plaa

Affiliations

  1. Département de Pharmacologie, Université de Montréal, Québec, Canada.

PMID: 8284793 DOI: 10.1016/0378-4274(94)90120-1

Abstract

The metabolic fate of methyl n-butyl ketone (MnBK) and its isomer methyl isobutyl ketone (MiBK) was studied in mice. The concentrations of both ketones and their metabolites in blood and brain were measured at different time intervals after their administration. The principal metabolites of MnBK were 2-hexanol (2-HOL) and 2,5-hexanedione (2,5-HD), while those of MiBK were 4-methyl-2-pentanol (4-MPOL) and 4-hydroxy-4 methyl-2-pentanone (HMP). The administration of 2-hexanol by itself led to the appearance of both MnBK and 2,5-hexanedione which, when administered by itself, did not lead to the appearance of either MnBK or 2-hexanol. The administration of 4-methyl-2-pentanol resulted in the appearance of MiBK and HMP. The administration of HMP did not result in the appearance of MiBK or 4-MPOL. These results indicate that the metabolic fate of MnBK and MiBK is similar to that reported in other species.

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