Eur Heart J. 1993 Nov;14:110-3.

Regional myocardial ischaemia and diastolic dysfunction in hypertensive heart disease.

European heart journal

J López Sendón

PMID: 8281954

Abstract

In patients with systemic hypertension there is progressive left ventricular remodelling characterized mainly by left ventricular hypertrophy accompanied by abnormal diastolic ventricular function. Regional ischaemia, secondary to abnormal myocardial perfusion may explain in part the decrease in relaxation and compliance of the hypertrophied left ventricle. Treatment with anti-ischaemia drugs, such as beta-blockers or calcium channel blockers, improve left ventricular diastolic function.

MeSH terms

• Diastole / physiology
• Humans
• Hypertension / complications
• Hypertrophy, Left Ventricular / drug therapy
• Hypertrophy, Left Ventricular / physiopathology
• Myocardial Ischemia / drug therapy
• Myocardial Ischemia / physiopathology
• Ventricular Function, Left

Publication Types

• Journal Article
• Review