Schweiz Med Wochenschr. 1977 Jan 08;107(1):17-22.

[Liver tumors and oral contraceptives. Report of a case and review of the liverature].

Schweizerische medizinische Wochenschrift

[Article in German]
J Kamber, F Michot, K J Villiger

PMID: 831247

Abstract

On laparotomy in a 33-year-old woman presenting with signs of chronic cholecystitis and cholelithiasis, a tumor (diameter 4.5 cm) of the right lobe of the liver was found and resected. It proved to be a hamartoma (focal nodular hyperplasia). At the age of 20 years the patient had been treated by radiation and chemotherapy for stage I Hodgkin's disease. Oral contraceptives had been prescribed for a period of 2 years. In the literature approximately 70 cases of chielfy benign liver tumors have been reported in women taking oral contraceptives. More than one third of these cases came to light because of life-threatening intraabdominal bleeding due to rupture of the tumor. A causative relationship between hepatic tumors and the use of oral contraceptives is suggested. As yet, however, there is no conclusive evidence to support this suggestion.

Keywords: Biology; Case Studies; Contraception; Contraceptive Methods--side effects; Developed Countries; Europe; Family Planning; Hepatic Effects; Literature Review; Oral Contraceptives--side effects; Physiology; Research Methodology; Studies; Switzerland; Western Europe

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Substances

• Contraceptives, Oral
• Contraceptives, Oral, Hormonal

MeSH terms

• Adult
• Cholecystectomy
• Cholelithiasis / surgery
• Contraceptives, Oral / adverse effects
• Contraceptives, Oral, Hormonal / adverse effects
• Female
• Hamartoma / chemically induced
• Hamartoma / surgery
• Hodgkin Disease / therapy
• Humans
• Liver Neoplasms / chemically induced

Publication Types

• Case Reports
• English Abstract
• Journal Article

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