Biol Pharm Bull. 1994 May;17(5):745-7. doi: 10.1248/bpb.17.745.

Chitosan and sodium alginate based bioadhesive tablets for intraoral drug delivery.

Biological & pharmaceutical bulletin

S Miyazaki, A Nakayama, M Oda, M Takada, D Attwood

PMID: 7920448 DOI: 10.1248/bpb.17.745

Abstract

Bioadhesive tablets for intraoral drug delivery were prepared by directly compressing the drug with a mixture of chitosan and sodium alginate in weight ratios of 4:1, 1:1 and 1:4, and the adhesion and release characteristics of the prepared systems were evaluated in vitro and in vivo. Ketoprofen was used as a model drug. The magnitudes of the adhesion force of chitosan/alginate tablets were observed to be comparable to that of Aftach, which is a typical commercial preparation of an oral mucosal adhesive tablet. Increasing the chitosan content in the tablets resulted in a decrease in the release rate of ketoprofen. When the tablets were administered to the sublingual site of rabbits, ketoprofen from the tablets with chitosan/alginate was rapidly absorbed without an initial sharp peak. Furthermore, the plasma concentration curves for the tablet with a 1:4 chitosan/alginate ratio showed a sustained release 3 h after administration. The data presented suggest that tablets prepared from chitosan and alginate are potential candidates for intraoral drug delivery.

Substances

• Alginates
• Hexuronic Acids
• Pharmaceutical Vehicles
• Tablets
• Chitin
• Glucuronic Acid
• Chitosan
• Ketoprofen

MeSH terms

• Adhesiveness
• Administration, Sublingual
• Alginates / chemistry
• Animals
• Chitin / analogs & derivatives
• Chitin / chemistry
• Chitosan
• Drug Delivery Systems*
• Glucuronic Acid
• Hexuronic Acids
• Intestinal Absorption
• Ketoprofen / administration & dosage
• Ketoprofen / pharmacokinetics
• Peritoneal Cavity
• Pharmaceutical Vehicles
• Rabbits
• Rats
• Solubility
• Tablets

Publication Types

• Journal Article