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Holscher HC, van der Woude HJ, Hermans J, et al. Magnetic resonance relaxation times of normal tissue in the course of chemotherapy: a study in patients with bone sarcoma. Skeletal Radiol. 1994;23(3):181-5doi: 10.1007/BF00197456.
Holscher, H. C., van der Woude, H. J., Hermans, J., Nooy, M. A., Doornbos, J., & Bloem, J. L. (1994). Magnetic resonance relaxation times of normal tissue in the course of chemotherapy: a study in patients with bone sarcoma. Skeletal radiology, 23(3), 181-5. https://doi.org/10.1007/BF00197456
Holscher, H C, et al. "Magnetic resonance relaxation times of normal tissue in the course of chemotherapy: a study in patients with bone sarcoma." Skeletal radiology vol. 23,3 (1994): 181-5. doi: https://doi.org/10.1007/BF00197456
Holscher HC, van der Woude HJ, Hermans J, Nooy MA, Doornbos J, Bloem JL. Magnetic resonance relaxation times of normal tissue in the course of chemotherapy: a study in patients with bone sarcoma. Skeletal Radiol. 1994 Apr;23(3):181-5. doi: 10.1007/BF00197456. PMID: 8016668.
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Skeletal Radiol. 1994 Apr;23(3):181-5. doi: 10.1007/BF00197456.

Magnetic resonance relaxation times of normal tissue in the course of chemotherapy: a study in patients with bone sarcoma.

Skeletal radiology

H C Holscher, H J van der Woude, J Hermans, M A Nooy, J Doornbos, J L Bloem

Affiliations

  1. Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.

PMID: 8016668 DOI: 10.1007/BF00197456

Abstract

To study the effect of chemotherapy on normal fat, skeletal muscle, and bone marrow, T1 and T2 relaxation times were measured in 15 patients with bone sarcoma before and after each cycle of preoperative chemotherapy. A section plane containing the tumor and if possible the nonaffected extremity was imaged with combined multiecho spin echo and inversion recovery pulse sequences. T1 and T2 relaxation times were calculated in the normal-appearing tissues. Although some variation was found in the values in the individual patient and between patients, no systematic changes of relaxation times of fat, muscle, or bone marrow occurred in the course of treatment. We conclude that the chemotherapy used in bone sarcoma has no effect on relaxation times of normal fat, muscle, and bone marrow, and that therefore these tissues may serve as a reference for the signal intensity of tumor.

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