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Sutherland BM. Photoreactivation: evaluation of pyrimidine dimers in ultraviolet radiation-induced cell transformation. Natl Cancer Inst Monogr. 1978;(50):129-32
Sutherland, B. M. (1978). Photoreactivation: evaluation of pyrimidine dimers in ultraviolet radiation-induced cell transformation. National Cancer Institute monograph, (50), 129-32.
Sutherland, B M. "Photoreactivation: evaluation of pyrimidine dimers in ultraviolet radiation-induced cell transformation." National Cancer Institute monograph vol. ,50 (1978): 129-32.
Sutherland BM. Photoreactivation: evaluation of pyrimidine dimers in ultraviolet radiation-induced cell transformation. Natl Cancer Inst Monogr. 1978 Dec;(50):129-32. PMID: 753970.
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Natl Cancer Inst Monogr. 1978 Dec;(50):129-32.

Photoreactivation: evaluation of pyrimidine dimers in ultraviolet radiation-induced cell transformation.

National Cancer Institute monograph

B M Sutherland

PMID: 753970

Abstract

The PRE repairs DNA by the specific and exclusive monomerization of pyrimidine dimers. Photoreactivation thus provides an analytical test for determining the role of pyrimidine dimers in UV damage to biologic systems. We have shown the first UV transformation of cultured human cells (judged by ability to grow in soft agar). Preliminary results indicate that 1) lesions leading to cell transformation are subject to photoreactivation and 2) pyrimidine dimers may well be important in solar carcinogenesis.

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