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American Society for Clinical Investigation Free PMC Article

J Clin Invest. 1994 Oct;94(4):1484-9. doi: 10.1172/JCI117487.

Sex-specific action of insulin to acutely increase the metabolic clearance rate of dehydroepiandrosterone in humans.

The Journal of clinical investigation

J E Nestler, Z Kahwash

Affiliations

  1. Department of Internal Medicine, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.

PMID: 7929824 PMCID: PMC295288 DOI: 10.1172/JCI117487
Free PMC Article

Abstract

To test the hypothesis that insulin acutely enhances the metabolic clearance rate (MCR) of dehydroepiandrosterone in humans, the effect of a short-term insulin infusion on the MCR of dehydroepiandrosterone was assessed in 10 men and 7 women. After an overnight fast, dehydroepiandrosterone was infused at 3.47 mumol/h for 6.5 h. At 240 min, a hyperinsulinemic-euglycemic clamp was begun by infusing insulin at 21.5 pmol/kg per min for 2.5 h. MCR of dehydroepiandrosterone was calculated at baseline (210-240 min) and during the insulin infusion (360-390 min). A control study was conducted at least 1 wk later, in which 0.45% saline was substituted for the hyperinsulinemic-euglycemic clamp. During the insulin clamp study, serum insulin rose from 34 +/- 2 to 1084 +/- 136 pmol/liter (P = 0.0001) in men and from 40 +/- 5 to 1357 +/- 175 pmol/liter (P = 0.0003) in women, while serum glucose remained constant in both groups. MCR of dehydroepiandrosterone rose in men during the insulin infusion from 2443 +/- 409 to 3599 +/- 500 liters/24 h (P = 0.003), but did not change during the control saline infusion. In contrast, MCR of dehydroepiandrosterone in women did not change in the insulin clamp study during insulin infusion (2526 +/- 495 liters/24 h at baseline vs. 2442 +/- 491 liters/24 h during insulin infusion; P = 0.78). These findings suggest that insulin acutely increases the MCR of dehydroepiandrosterone in men but not in women.

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References

  1. Cardiology. 1992;80(5-6):332-8 - PubMed
  2. Diabetes. 1993 Aug;42(8):1105-8 - PubMed
  3. J Endocrinol. 1973 Apr;57(1):123-34 - PubMed
  4. J Clin Endocrinol Metab. 1992 Feb;74(2):362-7 - PubMed
  5. J Clin Endocrinol Metab. 1993 Dec;77(6):1610-5 - PubMed
  6. Epidemiol Rev. 1991;13:267-93 - PubMed
  7. J Clin Endocrinol Metab. 1980 Aug;51(2):330-3 - PubMed
  8. FASEB J. 1992 Sep;6(12):3073-5 - PubMed
  9. Diabetes. 1982 Sep;31(9):830-3 - PubMed
  10. Ann Intern Med. 1992 Nov 15;117(10):807-11 - PubMed
  11. J Clin Endocrinol Metab. 1983 Aug;57(2):304-10 - PubMed
  12. Can J Biochem. 1975 Feb;53(2):215-22 - PubMed
  13. J Steroid Biochem. 1983 Jul;19(1B):607-14 - PubMed
  14. Can J Biochem. 1968 Sep;46(9):1031-8 - PubMed
  15. Atherosclerosis. 1989 Oct;79(2-3):197-203 - PubMed
  16. Lancet. 1993 Sep 18;342(8873):707-9 - PubMed
  17. J Clin Endocrinol Metab. 1989 Nov;69(5):1040-6 - PubMed
  18. N Engl J Med. 1986 Dec 11;315(24):1519-24 - PubMed
  19. J Clin Endocrinol Metab. 1993 May;76(5):1301-7 - PubMed
  20. J Clin Invest. 1988 Aug;82(2):712-20 - PubMed
  21. Acta Univ Carol Med Monogr. 1976;71:1-137, 146-71 - PubMed
  22. Lancet. 1967 Sep 2;2(7514):485-7 - PubMed
  23. J Clin Invest. 1993 Jul;92(1):147-54 - PubMed
  24. J Clin Endocrinol Metab. 1987 Jan;64(1):180-4 - PubMed
  25. J Clin Endocrinol Metab. 1990 Sep;71(3):696-704 - PubMed
  26. Biol Reprod. 1992 Mar;46(3):342-8 - PubMed
  27. J Clin Endocrinol Metab. 1991 Apr;72(4):883-7 - PubMed
  28. Circulation. 1993 Jan;87(1):261-9 - PubMed
  29. J Clin Endocrinol Metab. 1957 Sep;17(9):1051-62 - PubMed
  30. J Am Coll Cardiol. 1990 Nov;16(6):862-70 - PubMed
  31. J Clin Endocrinol Metab. 1990 Apr;70(4):1075-81 - PubMed
  32. Diabetes Care. 1991 Mar;14(3):173-94 - PubMed
  33. J Clin Endocrinol Metab. 1968 Nov;28(11):1525-33 - PubMed
  34. Maturitas. 1988 Dec;10(4):297-306 - PubMed
  35. J Clin Endocrinol Metab. 1987 Jun;64(6):1261-7 - PubMed
  36. J Clin Endocrinol Metab. 1984 Sep;59(3):551-5 - PubMed
  37. J Clin Endocrinol Metab. 1988 Jan;66(1):57-61 - PubMed
  38. Circulation. 1994 Jan;89(1):89-93 - PubMed
  39. J Pharmacol Exp Ther. 1992 May;261(2):686-91 - PubMed
  40. Ann Hum Biol. 1984 Jul-Aug;11(4):327-36 - PubMed
  41. Metabolism. 1993 Oct;42(10):1284-90 - PubMed
  42. J Clin Endocrinol Metab. 1980 Jan;50(1):117-21 - PubMed
  43. Experientia. 1977 Jul 15;33(7):966-7 - PubMed
  44. Diabetes. 1991 Jun;40(6):693-700 - PubMed
  45. J Steroid Biochem Mol Biol. 1991;40(4-6):599-605 - PubMed
  46. J Clin Endocrinol Metab. 1988 Jun;66(6):1329-31 - PubMed
  47. Hypertension. 1993 Nov;22(5):735-42 - PubMed
  48. Lancet. 1970 Aug 22;2(7669):390-1 - PubMed
  49. Steroids. 1991 Oct;56(10):524-6 - PubMed
  50. J Clin Endocrinol Metab. 1980 Aug;51(2):334-6 - PubMed
  51. Fertil Steril. 1990 Nov;54(5):788-92 - PubMed
  52. Diabetes. 1988 Dec;37(12):1595-607 - PubMed
  53. Am J Med Sci. 1993 Nov;306(5):320-4 - PubMed
  54. Arteriosclerosis. 1989 Mar-Apr;9(2):159-66 - PubMed
  55. J Clin Endocrinol Metab. 1994 Mar;78(3):549-54 - PubMed
  56. Circ Res. 1991 Sep;69(3):638-43 - PubMed
  57. Diabetes. 1984 Jan;33(1):26-32 - PubMed
  58. J Clin Invest. 1993 Oct;92(4):1981-5 - PubMed
  59. Diabetes. 1993 Jul;42(7):1073-81 - PubMed

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