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Fedorka-Cray PJ, Kelley LC, Stabel TJ, et al. Alternate routes of invasion may affect pathogenesis of Salmonella typhimurium in swine. Infect Immun. 1995;63(7):2658-64doi: 10.1128/iai.63.7.2658-2664.1995.
Fedorka-Cray, P. J., Kelley, L. C., Stabel, T. J., Gray, J. T., & Laufer, J. A. (1995). Alternate routes of invasion may affect pathogenesis of Salmonella typhimurium in swine. Infection and immunity, 63(7), 2658-64. https://doi.org/10.1128/iai.63.7.2658-2664.1995
Fedorka-Cray, P J, et al. "Alternate routes of invasion may affect pathogenesis of Salmonella typhimurium in swine." Infection and immunity vol. 63,7 (1995): 2658-64. doi: https://doi.org/10.1128/iai.63.7.2658-2664.1995
Fedorka-Cray PJ, Kelley LC, Stabel TJ, Gray JT, Laufer JA. Alternate routes of invasion may affect pathogenesis of Salmonella typhimurium in swine. Infect Immun. 1995 Jul;63(7):2658-64. doi: 10.1128/iai.63.7.2658-2664.1995. PMID: 7790082; PMCID: PMC173356.
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Atypon Free PMC Article

Infect Immun. 1995 Jul;63(7):2658-64. doi: 10.1128/iai.63.7.2658-2664.1995.

Alternate routes of invasion may affect pathogenesis of Salmonella typhimurium in swine.

Infection and immunity

P J Fedorka-Cray, L C Kelley, T J Stabel, J T Gray, J A Laufer

Affiliations

  1. USDA-Agricultural Research Service-National Animal Disease Center, Ames, Iowa 50010, USA.

PMID: 7790082 PMCID: PMC173356 DOI: 10.1128/iai.63.7.2658-2664.1995
Free PMC Article

Abstract

Transmission of Salmonella typhimurium in swine is traditionally believed to occur by the fecal-oral route, with invasion through the intestinal wall and Peyer's patches. However, involvement of the upper respiratory tract may be equally important. An esophagotomy was performed on 6- to 8-week-old pigs. Esophagotomized pigs were challenged intranasally with 10(9) CFU of S. typhimurium cells and necropsied at 3, 6, 12, and 18 h postinoculation (p.i.). By 3 h p.i., S. typhimurium was recovered from cecum, colon, head, and thoracic tissues and from the middle ileum involving a large number of Peyer's patches. The ileocolic lymph nodes and ileocolic junction were not positive for S. typhimurium until 6 and 12 h p.i., respectively. Additional pigs were inoculated transthoracically with 10(9) CFU of S. typhimurium and necropsied at 3 and 18 h p.i. By 3 h p.i., all tissues were positive for S. typhimurium. Tonsil explants seeded with 10(9) CFU of S. typhimurium indicated that within 6 h p.i., S. typhimurium was located within the tonsilar crypts. These data show that after intranasal inoculation, S. typhimurium rapidly appears in the gut tissues and suggest that the tonsils and lung may be important sites for invasion and dissemination of Salmonella species.

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