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Chu CM, Liaw YF. Coexpression of intercellular adhesion molecule-1 and class I major histocompatibility complex antigens on hepatocyte membrane in chronic viral hepatitis. J Clin Pathol. 1993;46(11):1004-8doi: 10.1136/jcp.46.11.1004.
Chu, C. M., & Liaw, Y. F. (1993). Coexpression of intercellular adhesion molecule-1 and class I major histocompatibility complex antigens on hepatocyte membrane in chronic viral hepatitis. Journal of clinical pathology, 46(11), 1004-8. https://doi.org/10.1136/jcp.46.11.1004
Chu, C M, and Liaw, Y F. "Coexpression of intercellular adhesion molecule-1 and class I major histocompatibility complex antigens on hepatocyte membrane in chronic viral hepatitis." Journal of clinical pathology vol. 46,11 (1993): 1004-8. doi: https://doi.org/10.1136/jcp.46.11.1004
Chu CM, Liaw YF. Coexpression of intercellular adhesion molecule-1 and class I major histocompatibility complex antigens on hepatocyte membrane in chronic viral hepatitis. J Clin Pathol. 1993 Nov;46(11):1004-8. doi: 10.1136/jcp.46.11.1004. PMID: 7902850; PMCID: PMC501682.
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J Clin Pathol. 1993 Nov;46(11):1004-8. doi: 10.1136/jcp.46.11.1004.

Coexpression of intercellular adhesion molecule-1 and class I major histocompatibility complex antigens on hepatocyte membrane in chronic viral hepatitis.

Journal of clinical pathology

C M Chu, Y F Liaw

Affiliations

  1. Liver Unit, Chang Gung Memorial Hospital, Taipei, Taiwan.

PMID: 7902850 PMCID: PMC501682 DOI: 10.1136/jcp.46.11.1004
Free PMC Article

Abstract

AIMS: To evaluate the role of hepatocyte expression of leucocyte adhesion molecules and major histocompatibility complex (MHC) antigens in the pathogenesis of chronic viral hepatitis.

METHODS: The expression of intercellular adhesion molecule 1 (ICAM-1), lymphocyte function associated antigen 3 (LFA-3), and MHC class I and II antigens on hepatocyte membrane in relation to the histological and biochemical activities was studied in patients with chronic B hepatitis, chronic persistent hepatitis (CPH) n = 23; chronic active hepatitis (CAH) n = 20; chronic D hepatitis (CAH) n = 6; and chronic non-A, non-B hepatitis (CPH n = 4, CAM n = 6). Six of the latter were hepatitis C virus antibody positive.

RESULTS: In chronic B hepatitis ICAM-1 and MHC-I were expressed significantly more in patients with CAH than in those with CPH (p < 0.001), while the expression of LFA-3 and MHC-II showed no significant difference, irrespective of serum HBeAg or hepatitis B virus DNA. Similar findings were noted in non-A, non-B hepatitis. Regardless of the viral aetiology, patients with CAH had a significantly higher degree of ICAM-1 and MHC-I expression than LFA-3 (p < 0.001 v ICAM-1 and MHC-I, respectively) and MHC-II (p < 0.001 v ICAM-1 and MHC-I, respectively) expression. Those with CPH showed little or no difference in the expression of these four molecules. Furthermore, serum ALT values positively correlated with the hepatocyte expression of ICAM-1 (p < 0.001) and MHC-I (p < 0.001), but not LFA-3 (p > 0.05) and MHC-II (p > 0.05).

CONCLUSIONS: In chronic viral hepatitis hepatocyte expression of ICAM-1 and MHC-I might be important for immunosurveillance against virally infected hepatocytes, while the expression of LFA-3 and MHC-II does not seem to have a role in the pathogenesis of chronic viral hepatitis.

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