Display options
Cite
Rush CR, Higgins ST, Hughes JR, et al. A comparison of the acute behavioral effects of triazolam and temazepam in normal volunteers. Psychopharmacology (Berl). 1993;112(4):407-14doi: 10.1007/BF02244887.
Rush, C. R., Higgins, S. T., Hughes, J. R., & Bickel, W. K. (1993). A comparison of the acute behavioral effects of triazolam and temazepam in normal volunteers. Psychopharmacology, 112(4), 407-14. https://doi.org/10.1007/BF02244887
Rush, C R, et al. "A comparison of the acute behavioral effects of triazolam and temazepam in normal volunteers." Psychopharmacology vol. 112,4 (1993): 407-14. doi: https://doi.org/10.1007/BF02244887
Rush CR, Higgins ST, Hughes JR, Bickel WK. A comparison of the acute behavioral effects of triazolam and temazepam in normal volunteers. Psychopharmacology (Berl). 1993;112(4):407-14. doi: 10.1007/BF02244887. PMID: 7871050.
Copy Download .nbib Format: NLM
Share it on

Psychopharmacology (Berl). 1993;112(4):407-14. doi: 10.1007/BF02244887.

A comparison of the acute behavioral effects of triazolam and temazepam in normal volunteers.

Psychopharmacology

C R Rush, S T Higgins, J R Hughes, W K Bickel

Affiliations

  1. Department of Psychiatry, University of Vermont 05401.

PMID: 7871050 DOI: 10.1007/BF02244887

Abstract

Two experiments were conducted to assess the acute behavioral effects of triazolam and temazepam in healthy, non-drug abusing men in double-blind, placebo-controlled, crossover trials, where all subjects received all possible doses. These drugs were compared to examine allegations that triazolam produces greater behavioral impairment than temazepam. Drug effects were assessed during 4-h sessions using measures of recall, learning, psychomotor performance, and subject ratings assessing drug effects and abuse potential. In experiment 1, triazolam (0.25 and 0.5 mg/70 kg) produced greater behavioral impairment than temazepam (15 and 30 mg/70 kg). However, triazolam also produced greater increases than temazepam in subject ratings of drug strength, drunkenness and sleepiness, suggesting the dose ranges compared may not have been clinically equivalent. Experiment 2 was conducted to assess whether a higher dose of temazepam than tested in experiment 1 would produce levels of behavioral impairment comparable to those observed with triazolam in experiment 1. In experiment 2, the temazepam dose was increased to 60 mg/70 kg while the triazolam dose was 0.5 mg/70 kg which was the highest dose tested in experiment 1. These doses produced comparable increases in subject ratings of drug strength, drunkenness and sleepiness, but temazepam produced significantly more behavioral disruption than triazolam. These findings do not support the position that triazolam produces greater behavioral impairment than temazepam, and may even suggest that across a wide range of doses triazolam is less disruptive than temazepam.

References

  1. JAMA. 1987 Aug 21;258(7):945-6 - PubMed
  2. J Pharmacol Exp Ther. 1993 Mar;264(3):1218-26 - PubMed
  3. J Pharmacol Exp Ther. 1987 Dec;243(3):978-88 - PubMed
  4. Pharmacol Biochem Behav. 1987 Apr;26(4):801-12 - PubMed
  5. Arzneimittelforschung. 1990 Aug;40(8):859-62 - PubMed
  6. Lancet. 1991 Oct 12;338(8772):938 - PubMed
  7. Drug Alcohol Depend. 1991 Jun;28(1):83-111 - PubMed
  8. Arch Intern Med. 1991 Oct;151(10):2003-8 - PubMed
  9. Percept Mot Skills. 1966 Dec;23(3):1287-93 - PubMed
  10. J Emerg Med. 1989 Mar-Apr;7(2):153-5 - PubMed
  11. Lancet. 1991 Apr 6;337(8745):827-31 - PubMed
  12. J Clin Psychopharmacol. 1983 Apr;3(2):133-9 - PubMed
  13. Pharmacology. 1987;35(5):286-300 - PubMed
  14. Clin Pharmacol Ther. 1991 Apr;49(4):468-76 - PubMed
  15. Arch Gen Psychiatry. 1989 Apr;46(4):326-32 - PubMed
  16. J Clin Psychopharmacol. 1990 Jun;10(3):160-7 - PubMed
  17. J Clin Psychiatry. 1988 Apr;49(4):134-7 - PubMed
  18. Lancet. 1979 Sep 8;2(8141):526 - PubMed
  19. Sleep. 1984;7(3):223-9 - PubMed

Substances

MeSH terms

Publication Types

Grant support