Biophys J. 1995 Mar;68(3):946-8. doi: 10.1016/S0006-3495(95)80270-5.
Biophysical journal
G D Lamb, D G Stephenson
PMID: 7756558 PMCID: PMC1281818 DOI: 10.1016/S0006-3495(95)80270-5 Free PMC Article
Flash photolysis of DM-nitrophen generates an extremely large [Ca2+] transient ("Ca2+ spike") at the start of each Ca2+ "step." The Ca2+ spike greatly increases the speed of activation of the ryanodine receptor channel ("supercharging") and could be responsible for apparent channel adaptation.