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Duguay AB, Plaa GL. Tissue concentrations of methyl isobutyl ketone, methyl n-butyl ketone and their metabolites after oral or inhalation exposure. Toxicol Lett. 1995;75(1):51-8doi: 10.1016/0378-4274(94)03155-z.
Duguay, A. B., & Plaa, G. L. (1995). Tissue concentrations of methyl isobutyl ketone, methyl n-butyl ketone and their metabolites after oral or inhalation exposure. Toxicology letters, 75(1), 51-8. https://doi.org/10.1016/0378-4274(94)03155-z
Duguay, A B, and Plaa, G L. "Tissue concentrations of methyl isobutyl ketone, methyl n-butyl ketone and their metabolites after oral or inhalation exposure." Toxicology letters vol. 75,1 (1995): 51-8. doi: https://doi.org/10.1016/0378-4274(94)03155-z
Duguay AB, Plaa GL. Tissue concentrations of methyl isobutyl ketone, methyl n-butyl ketone and their metabolites after oral or inhalation exposure. Toxicol Lett. 1995 Jan;75(1):51-8. doi: 10.1016/0378-4274(94)03155-z. PMID: 7863537.
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Toxicol Lett. 1995 Jan;75(1):51-8. doi: 10.1016/0378-4274(94)03155-z.

Tissue concentrations of methyl isobutyl ketone, methyl n-butyl ketone and their metabolites after oral or inhalation exposure.

Toxicology letters

A B Duguay, G L Plaa

Affiliations

  1. Département de pharmacologie, Faculté de médecine, Université de Montréal, Québec, Canada.

PMID: 7863537 DOI: 10.1016/0378-4274(94)03155-z

Abstract

Quantitative relationships between plasma, liver and lung methyl isobutyl ketone (MiBK) and methyl n-butyl ketone (MnBK) concentrations after oral or inhalation exposure were established. Their respective metabolites (4-methyl-2-pentanol, 4-hydroxy-methyl isobutyl ketone, 2-hexanol, and 2,5-hexanedione) were also quantified. Male Sprague-Dawley rats were exposed for 3 days to MiBK or MnBK vapors (4 h/day) or treated orally for 3 days with a MiBK- or MnBK-corn oil solution. Both ketones and their respective metabolites in plasma or tissue concentrations were determined by gas chromatography. MiBK and MnBK plasma and tissue concentrations increased in a dose-related manner with the administered dose irrespective of the route of administration. Metabolite concentrations, however, were influenced by the route of administration.

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