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Murata A, Toda H, Uda K, et al. Protective effect of recombinant neutrophil elastase inhibitor (R-020) on sepsis-induced organ injury in rat. Inflammation. 1994;18(4):337-47doi: 10.1007/BF01534432.
Murata, A., Toda, H., Uda, K., Hayashida, H., Kato, T., Nakagawa, H., Yokoyama, S., Morishita, H., Yamakawa, T., & Hirose, J. (1994). Protective effect of recombinant neutrophil elastase inhibitor (R-020) on sepsis-induced organ injury in rat. Inflammation, 18(4), 337-47. https://doi.org/10.1007/BF01534432
Murata, A, et al. "Protective effect of recombinant neutrophil elastase inhibitor (R-020) on sepsis-induced organ injury in rat." Inflammation vol. 18,4 (1994): 337-47. doi: https://doi.org/10.1007/BF01534432
Murata A, Toda H, Uda K, Hayashida H, Kato T, Nakagawa H, Yokoyama S, Morishita H, Yamakawa T, Hirose J. Protective effect of recombinant neutrophil elastase inhibitor (R-020) on sepsis-induced organ injury in rat. Inflammation. 1994 Aug;18(4):337-47. doi: 10.1007/BF01534432. PMID: 7527012.
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Inflammation. 1994 Aug;18(4):337-47. doi: 10.1007/BF01534432.

Protective effect of recombinant neutrophil elastase inhibitor (R-020) on sepsis-induced organ injury in rat.

Inflammation

A Murata, H Toda, K Uda, H Hayashida, T Kato, H Nakagawa, S Yokoyama, H Morishita, T Yamakawa, J Hirose

Affiliations

  1. Department of Surgery II, Osaka University Medical School, Japan.

PMID: 7527012 DOI: 10.1007/BF01534432

Abstract

Severe inflammatory responses after major surgeries, trauma, and infection develop multiple organ dysfunction. In the mechanisms of the pathogenesis of these responses, activated neutrophils are thought to be important in terms of their ability to produce various kinds of proteinases, which can degrade various proteins constructing human tissues. Among their proteinases, neutrophil elastase is the strongest serine proteinase secreted from activated neutrophils. Thus, we examined in this study the inhibitory effect and therapeutic efficacy of newly produced recombinant human Kunitz-type proteinase inhibitor (R-020), which coded the second domain of human urinary trypsin inhibitor. R-020 was effective in significantly improving the survival rate after induction of the rat lethal peritonitis model (cecal ligation and puncture-induced septic shock model). We suggest that various serine proteinases are implicated in the pathogenesis of neutrophil-related multiple organ failure and that recombinant human Kunitz-type proteinase inhibitor might be effective in the treatment of these kinds of organ dysfunction.

References

  1. Surgery. 1992 Aug;112(2):188-93; discussion 193-4 - PubMed
  2. Jpn J Pharmacol. 1992 Nov;60(3):239-45 - PubMed
  3. J Anesth. 1990 Jan;4(1):40-4 - PubMed
  4. J Surg Res. 1980 Aug;29(2):189-201 - PubMed
  5. Crit Care Med. 1992 Jun;20(6):891-8 - PubMed
  6. Thorax. 1992 Apr;47(4):260-3 - PubMed
  7. Annu Rev Med. 1985;36:207-16 - PubMed
  8. Resuscitation. 1986 Sep;14(1-2):3-21 - PubMed
  9. Thromb Res. 1994 Feb 15;73(3-4):193-204 - PubMed
  10. Clin Ther. 1990 Jul-Aug;12 (4):323-6 - PubMed
  11. Chest. 1993 Mar;103(3):932-43 - PubMed
  12. Chest. 1992 Jun;101(6):1644-55 - PubMed
  13. J Med. 1991;22(6):371-82 - PubMed
  14. Jpn J Pharmacol. 1985 Oct;39(2):137-44 - PubMed
  15. Crit Care Med. 1992 Aug;20(8):1134-9 - PubMed
  16. Chest. 1992 Aug;102(2):613-7 - PubMed
  17. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
  18. J Surg Res. 1993 Jul;55(1):1-8 - PubMed
  19. N Engl J Med. 1989 Feb 9;320(6):365-76 - PubMed
  20. Physiol Rev. 1990 Apr;70(2):427-51 - PubMed

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