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Keränen U, Kiviluoto T, Järvinen H, et al. Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis. Dig Dis Sci. 1995;40(10):2250-8doi: 10.1007/BF02209015.
Keränen, U., Kiviluoto, T., Järvinen, H., Bäck, N., Kivilaakso, E., & Soinila, S. (1995). Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis. Digestive diseases and sciences, 40(10), 2250-8. https://doi.org/10.1007/BF02209015
Keränen, U, et al. "Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis." Digestive diseases and sciences vol. 40,10 (1995): 2250-8. doi: https://doi.org/10.1007/BF02209015
Keränen U, Kiviluoto T, Järvinen H, Bäck N, Kivilaakso E, Soinila S. Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis. Dig Dis Sci. 1995 Oct;40(10):2250-8. doi: 10.1007/BF02209015. PMID: 7587798.
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Dig Dis Sci. 1995 Oct;40(10):2250-8. doi: 10.1007/BF02209015.

Changes in substance P-immunoreactive innervation of human colon associated with ulcerative colitis.

Digestive diseases and sciences

U Keränen, T Kiviluoto, H Järvinen, N Bäck, E Kivilaakso, S Soinila

Affiliations

  1. Second Department of Surgery, Helsinki University Central Hospital, Finland.

PMID: 7587798 DOI: 10.1007/BF02209015

Abstract

The amount of colonic substance P and substance P-receptors is increased in ulcerative colitis, which may denote that substance-P is involved as a neurogenic mediator in the inflammatory process of ulcerative colitis. We studied the anatomical distribution of elevated colonic substance P in ulcerative colitis and assessed morphometrically whether the changes in substance P correlate with alterations in colonic innervation. Full-thickness specimens of colonic wall were obtained from normal human colons (N = 9) and the most and least affected regions of ulcerative colitis colons (N = 10) and immunostained for substance P. Substance P immunoreactivity index was calculated by multiplying each intensity value by the number of pixels exhibiting this intensity value. The numbers of substance P-immunoreactive nerve fibers in the lamina propria were markedly increased, and their fluorescence intensity was enhanced in ulcerative colitis. The longitudinal muscle layer contained substance P-immunoreactive nerve fibers in ulcerative colitis, but not in the controls. The substance P-immunoreactive index (= number x intensity of nerve fibers) was 3.42 +/- 1.49 in controls, 21.19 +/- 7.79 in mild ulcerative colitis regions (P < 0.05), and 29.68 +/- 9.81 in severe ulcerative colitis regions (P < 0.01). Increase in the number of substance P nerve fibers is in accordance with the hypothesis that substance P contributes to neurogenic mediation of inflammation in ulcerative colitis.

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