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Inflammation. 1994 Jun;18(3):285-92. doi: 10.1007/BF01534269.

Modulation of carrageenan-induced hind paw edema by substance P.

Inflammation

J P Gilligan, S J Lovato, M D Erion, A Y Jeng

Affiliations

  1. Unigene Laboratories, Fairfield, New Jersey 07006.

PMID: 7522223 DOI: 10.1007/BF01534269

Abstract

Substance P has been implicated as a mediator of inflammation. The involvement of this neuropeptide in carrageenan-induced hind paw edema in the rat was assessed. Subcutaneous injection of carrageenan into the rat paw caused a significant increase in substance P levels, which preceded the onset of inflammation. While injection of substance P alone caused mild edema, coadministration of submaximal doses of carrageenan and substance P resulted in a synergistic exacerbation in the degree of inflammation. This synergistic response was not detected when the nonamidated precursor of substance P was coinjected with carrageenan. The effects of substance P depletion on inflammation were also evaluated. In animals pretreated with capsaicin followed by injection with carrageenan, no significant increase in either the levels of substance P or the extent of edema was observed when compared to capsaicin-treated controls. These results indicate that substance P may play an important role in the early stages of carrageenan-induced paw edema and that a reduction in the biosynthesis of substance P may lessen the severity of this inflammatory response.

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