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Villari D, Rubino F, Corica F, et al. Bile ductopenia following therapy with sulpiride. Virchows Arch. 1995;427(2):223-6doi: 10.1007/BF00196529.
Villari, D., Rubino, F., Corica, F., Spinella, S., Di Cesare, E., Longo, G., & Raimondo, G. (1995). Bile ductopenia following therapy with sulpiride. Virchows Archiv : an international journal of pathology, 427(2), 223-6. https://doi.org/10.1007/BF00196529
Villari, D, et al. "Bile ductopenia following therapy with sulpiride." Virchows Archiv : an international journal of pathology vol. 427,2 (1995): 223-6. doi: https://doi.org/10.1007/BF00196529
Villari D, Rubino F, Corica F, Spinella S, Di Cesare E, Longo G, Raimondo G. Bile ductopenia following therapy with sulpiride. Virchows Arch. 1995;427(2):223-6. doi: 10.1007/BF00196529. PMID: 7582254.
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Virchows Arch. 1995;427(2):223-6. doi: 10.1007/BF00196529.

Bile ductopenia following therapy with sulpiride.

Virchows Archiv : an international journal of pathology

D Villari, F Rubino, F Corica, S Spinella, E Di Cesare, G Longo, G Raimondo

Affiliations

  1. Dipartimento di Patologia Umana, Università di Messina, Italy.

PMID: 7582254 DOI: 10.1007/BF00196529

Abstract

We report a case of ductopenia associated with cholestatic hepatitis in a 59-year-old woman treated for 41 years for temporal epilepsy. The patient developed jaundice, without any clinical or biochemical features of hypersensitivity, 10 months after the beginning of treatment with sulpiride. Liver biopsy showed ballooning and acidophilic degeneration of the hepatocytes, macrophages packed with lipofuscin, biliary pigment in Kupffer cells, some biliary plugs, confluent necrosis and absence of biliary ducts in all the portal tracts. These features and the presence of foci of cholangiolitis suggest a destructive cholangitis as the pathogenetic mechanism causing ductopenia. Other causes of ductopenia were excluded. Sulpiride is known to produce severe cholestatic jaundice, which we believe is due to ductopenia. The absence of hypersensitivity and the 10-month latency suggest that sulpiride may cause liver damage through a toxic mechanism in genetically susceptible subjects.

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