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Atypon Free PMC Article

Antimicrob Agents Chemother. 1995 Jun;39(6):1336-40. doi: 10.1128/AAC.39.6.1336.

Interleukin 10 reduces mortality from severe peritonitis in mice.

Antimicrobial agents and chemotherapy

T Kato, A Murata, H Ishida, H Toda, N Tanaka, H Hayashida, M Monden, N Matsuura

Affiliations

  1. Department of Surgery II, Osaka University Medical School, Japan.

PMID: 7574526 PMCID: PMC162737 DOI: 10.1128/AAC.39.6.1336
Free PMC Article

Abstract

Interleukin 10 (IL-10) is known to suppress the induction of proinflammatory cytokines such as tumor necrosis factor (TNF) and IL-1 and is itself induced by monocytes and macrophages during sepsis. We studied the therapeutic efficacy of IL-10 by testing its effect on the survival rate in the murine cecal ligation-and-puncture (CLP) model. Administration of 1 microgram or more of recombinant murine IL-10 6 h after induction of sepsis decreased lethality in septic mice significantly and also suppressed the elevation of circulating TNF after sepsis. However, treatment with the same dose of IL-10 simultaneously or 6 h before induction of CLP had no effect on survival, and treatment with anti-TNF antibody after induction of CLP had no effect on the survival rate. These data suggest that cytokine modulation with IL-10 is a potential candidate for the treatment of sepsis and sepsis-related multiple organ failure.

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