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Bartlett AJ, Lloyd-Jones JG, Rance MJ, et al. The radioimmunoassay of buprenorphine. Eur J Clin Pharmacol. 1980;18(4):339-45doi: 10.1007/BF00561392.
Bartlett, A. J., Lloyd-Jones, J. G., Rance, M. J., Flockhart, I. R., Dockray, G. J., Bennett, M. R., & Moore, R. A. (1980). The radioimmunoassay of buprenorphine. European journal of clinical pharmacology, 18(4), 339-45. https://doi.org/10.1007/BF00561392
Bartlett, A J, et al. "The radioimmunoassay of buprenorphine." European journal of clinical pharmacology vol. 18,4 (1980): 339-45. doi: https://doi.org/10.1007/BF00561392
Bartlett AJ, Lloyd-Jones JG, Rance MJ, Flockhart IR, Dockray GJ, Bennett MR, Moore RA. The radioimmunoassay of buprenorphine. Eur J Clin Pharmacol. 1980 Oct;18(4):339-45. doi: 10.1007/BF00561392. PMID: 7439255.
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Eur J Clin Pharmacol. 1980 Oct;18(4):339-45. doi: 10.1007/BF00561392.

The radioimmunoassay of buprenorphine.

European journal of clinical pharmacology

A J Bartlett, J G Lloyd-Jones, M J Rance, I R Flockhart, G J Dockray, M R Bennett, R A Moore

PMID: 7439255 DOI: 10.1007/BF00561392

Abstract

Antisera to buprenorphine were obtained in rabbits immunised with 3-0-carboxymethylbuprenorphine and N-hemisuccinyl-norbuprenorphine conjugated to bovine serum albumin. Using the latter antiserum and tritium labelled buprenorphine a radioimmunoassay have good accuracy and precision was developed for concentrations as low as 50 picograms in 1 ml of plasma. The N-hemisuccinyl antiserum crossreacted with norbuprenorphine, and the 3-0-glucuronide conjugate with the 3-0-carboxymethyl antiserum. Cross-reactivity of both antisera to other pharmacologically related compounds was negligible. The assay was employed to determine plasma buprenorphine concentration following its parenteral administration to dog and man.

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