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Johansson RS, Falch DK. 113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR). The binding of 113mIn to DTPA and a comparison between GFR estimated with 113mIn-DTPA and 125I-iothalamate. Eur J Nucl Med. 1978;3(3):179-81doi: 10.1007/BF00256640.
Johansson, R. S., & Falch, D. K. (1978). 113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR). The binding of 113mIn to DTPA and a comparison between GFR estimated with 113mIn-DTPA and 125I-iothalamate. European journal of nuclear medicine, 3(3), 179-81. https://doi.org/10.1007/BF00256640
Johansson, R S, and Falch, D K. "113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR). The binding of 113mIn to DTPA and a comparison between GFR estimated with 113mIn-DTPA and 125I-iothalamate." European journal of nuclear medicine vol. 3,3 (1978): 179-81. doi: https://doi.org/10.1007/BF00256640
Johansson RS, Falch DK. 113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR). The binding of 113mIn to DTPA and a comparison between GFR estimated with 113mIn-DTPA and 125I-iothalamate. Eur J Nucl Med. 1978 Jul 01;3(3):179-81. doi: 10.1007/BF00256640. PMID: 738287.
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Eur J Nucl Med. 1978 Jul 01;3(3):179-81. doi: 10.1007/BF00256640.

113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR). The binding of 113mIn to DTPA and a comparison between GFR estimated with 113mIn-DTPA and 125I-iothalamate.

European journal of nuclear medicine

R S Johansson, D K Falch

PMID: 738287 DOI: 10.1007/BF00256640

Abstract

For measurement of glomerular filtration rate the usefulness of diethyl traimino penta acic (DTPA) labelled with 113mIndium has been explored. The labelling procedure is very simple, since eluate from an 113mIn generator can be used directly for labelling DTP. The in vitro and in vivo binding of 113mIn to DTPA in competition with serum proteins was studied by gel-filtration. The radioactivity with the 113mIn-DTPA peak represented 100.6, 107.1 and 99.6% of the amount of radioactivity applied to the gel column for the in vivo studies, and 102.0 and 101.4% for the in vitro studies. Futhermore, the clearance of 113mIn-DTPA was compared to the clearance of 125I-iothalamate using the constant infusion technique. The clearance values were found to be nearly equal (r=0.996). It is concluded that 113mIn is almost entirely bound to DTPA after intravenous injection of the 113mIn-DTPA complex, and that the complex is a suitable agent for determination of glomerular filtration rate.

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References

  1. J Nucl Med. 1972 Jan;13(1):107-10 - PubMed
  2. Biomedicine. 1974 May;20(3):192-7 - PubMed
  3. Scand J Clin Lab Invest. 1972 Dec;30(4):395-403 - PubMed
  4. Br J Radiol. 1967 Aug;40(476):581-3 - PubMed
  5. J Lab Clin Med. 1970 May;75(5):711-20 - PubMed
  6. J Nucl Med. 1977 Feb;18(2):112-7 - PubMed

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