Science. 1980 Dec 05;210(4474):1143-5. doi: 10.1126/science.7444444.

Electrophysiological correlates of ethanol-induced sedation in differentially sensitive lines of mice.

Science (New York, N.Y.)

S Sorensen, M Palmer, T Dunwiddie, B Hoffer

PMID: 7444444 DOI: 10.1126/science.7444444

Abstract

Acute electrophysiological effects of ethanol were studied in two lines of mice that differ markedly in their response to the soporific effects of systemic alcohol administration. Cerebellar Purkinje neurons from the genetic line that had long sleep times were one to two orders of magnitude more sensitive to the depressant effects of locally administered ethanol than those from the line that had short sleep times. The data suggest that there are genetically determined specificities in the acute effects of ethanol on central neurons and that such specificities might be used to determine which regions of the cerebellum participate in differences in behavioral responses to this substance.

Substances

• Ethanol

MeSH terms

• Action Potentials / drug effects
• Animals
• Behavior, Animal / physiology
• Dose-Response Relationship, Drug
• Ethanol / pharmacology
• Heart Conduction System / drug effects
• Mice
• Mice, Mutant Strains
• Neural Inhibition / drug effects
• Purkinje Fibers / drug effects

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't
• Research Support, U.S. Gov't, P.H.S.

Grant support

• AA-03527/AA/NIAAA NIH HHS/United States
• GM-01983/GM/NIGMS NIH HHS/United States

LinkOut - more resources

• Full Text Sources
  • Atypon