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Lloyd-Jones JG, Robinson P, Henson R, et al. Plasma concentration and disposition of buprenorphine after intravenous and intramuscular doses to baboons. Eur J Drug Metab Pharmacokinet. 1980;5(4):233-9doi: 10.1007/BF03189469.
Lloyd-Jones, J. G., Robinson, P., Henson, R., Biggs, S. R., & Taylor, T. (1980). Plasma concentration and disposition of buprenorphine after intravenous and intramuscular doses to baboons. European journal of drug metabolism and pharmacokinetics, 5(4), 233-9. https://doi.org/10.1007/BF03189469
Lloyd-Jones, J G, et al. "Plasma concentration and disposition of buprenorphine after intravenous and intramuscular doses to baboons." European journal of drug metabolism and pharmacokinetics vol. 5,4 (1980): 233-9. doi: https://doi.org/10.1007/BF03189469
Lloyd-Jones JG, Robinson P, Henson R, Biggs SR, Taylor T. Plasma concentration and disposition of buprenorphine after intravenous and intramuscular doses to baboons. Eur J Drug Metab Pharmacokinet. 1980;5(4):233-9. doi: 10.1007/BF03189469. PMID: 7250147.
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Eur J Drug Metab Pharmacokinet. 1980;5(4):233-9. doi: 10.1007/BF03189469.

Plasma concentration and disposition of buprenorphine after intravenous and intramuscular doses to baboons.

European journal of drug metabolism and pharmacokinetics

J G Lloyd-Jones, P Robinson, R Henson, S R Biggs, T Taylor

PMID: 7250147 DOI: 10.1007/BF03189469

Abstract

Buprenorphine is a newly-developed strong analgesic. A selected ion monitoring method has been developed to measure its plasma levels over the concentration range 20-3000ng ml-1. Six baboons each received intravenous and intramuscular doses of buprenorphine hydrochloride at a level of 5mg/kg in a cross-over study. The mean peak plasma concentrations (+/-standard deviation) were 2290 +/- 357ng ml-1 and 805 +/- 416ng ml-1 respectively and the corresponding times to the peak levels were 4.0 +/- 1.5 minutes and 30.3 +/- 24.6 minutes suggesting the rapid release of the drug from intramuscular sites. Comparison of areas under the plasma concentration versus time curves to 24 hours after dosing showed the mean bioavailability of buprenorphine from the intramuscular doses was 70% of that from the reference intravenous doses.

References

  1. J Pharm Sci. 1978 Feb;67(2):260-1 - PubMed
  2. Acta Anaesthesiol Belg. 1976;27(3):187-91 - PubMed
  3. J Pharmacol Exp Ther. 1971 Aug;178(2):253-8 - PubMed
  4. Acta Pharm Suec. 1971 Mar;8(1):27-38 - PubMed
  5. J Pharmacokinet Biopharm. 1978 Dec;6(6):505-19 - PubMed
  6. Toxicol Appl Pharmacol. 1971 Jul;19(3):480-92 - PubMed
  7. J Pharmacol Exp Ther. 1976 Mar;196(3):642-8 - PubMed
  8. Br J Anaesth. 1978 Jun;50(6):605-9 - PubMed
  9. Br J Pharmacol. 1971 Oct;43(2):461P-462P - PubMed
  10. Clin Pharmacol Ther. 1975 Oct;18(4):449-56 - PubMed

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