Display options
Cite
Ochs HR, Greenblatt DJ, Otten H. Disposition of oxazepam in relation to age, sex, and cigarette smoking. Klin Wochenschr. 1981;59(16):899-903doi: 10.1007/BF01721923.
Ochs, H. R., Greenblatt, D. J., & Otten, H. (1981). Disposition of oxazepam in relation to age, sex, and cigarette smoking. Klinische Wochenschrift, 59(16), 899-903. https://doi.org/10.1007/BF01721923
Ochs, H R, et al. "Disposition of oxazepam in relation to age, sex, and cigarette smoking." Klinische Wochenschrift vol. 59,16 (1981): 899-903. doi: https://doi.org/10.1007/BF01721923
Ochs HR, Greenblatt DJ, Otten H. Disposition of oxazepam in relation to age, sex, and cigarette smoking. Klin Wochenschr. 1981 Aug 17;59(16):899-903. doi: 10.1007/BF01721923. PMID: 7278081.
Copy Download .nbib Format: NLM
Share it on

Klin Wochenschr. 1981 Aug 17;59(16):899-903. doi: 10.1007/BF01721923.

Disposition of oxazepam in relation to age, sex, and cigarette smoking.

Klinische Wochenschrift

H R Ochs, D J Greenblatt, H Otten

PMID: 7278081 DOI: 10.1007/BF01721923

Abstract

The kinetics of single 30-mg oral doses of oxazepam were determined in 22 male and nine female volunteers aged 20-86 years. Oxazepam plasma concentrations were measured in multiple plasma samples drawn during 36 h after each dose. Mean kinetic variables in males and females, respectively, were: elimination half-life, 7.5 and 8.5 h; volume of distribution, 0.96 and 1.17 l/kg; clearance, 1.48 and 1.70 ml/min/kg. Sex differences were not significant, nor were any of the kinetic variables significantly related to age. However, oxazepam clearance increased significantly with heavier cigarette smoking (r = 0.48, p less than 0.01). Mean clearance in smokers (1.98 ml/min/kg) was significantly higher than in nonsmokers (1.23 ml/min/kg, p less than 0.01). Thus, smoking is a more important determinant of oxazepam clearance than age or sex.

References

  1. Drugs. 1978 Oct;16(4):358-82 - PubMed
  2. Anesthesiology. 1979 Aug;51(2):154-9 - PubMed
  3. Drug Metab Rev. 1979;9(2):221-36 - PubMed
  4. J Pharm Sci. 1979 Oct;68(10):1320-2 - PubMed
  5. Clin Pharmacol Ther. 1978 Apr;23(4):371-4 - PubMed
  6. N Engl J Med. 1973 Feb 8;288(6):277-80 - PubMed
  7. Clin Pharmacol Ther. 1978 Oct;24(4):411-9 - PubMed
  8. Br Med J. 1977 Jan 1;1(6052):10-2 - PubMed
  9. Br J Clin Pharmacol. 1978 May;5(5):407-13 - PubMed
  10. J Pharmacol Exp Ther. 1980 Oct;215(1):86-91 - PubMed
  11. J Chromatogr. 1978 Sep 1;146(2):311-20 - PubMed
  12. J Pharm Sci. 1979 Jan;68(1):57-63 - PubMed
  13. Psychopharmacology (Berl). 1977 Nov 15;54(3):277-82 - PubMed
  14. J Clin Pharmacol. 1977 Nov-Dec;17(11-12):709-18 - PubMed
  15. Clin Pharmacol Ther. 1977 Mar;21(3):355-61 - PubMed
  16. Gastroenterology. 1978 Sep;75(3):479-85 - PubMed
  17. Clin Pharmacol Ther. 1980 Mar;27(3):301-12 - PubMed
  18. Clin Pharmacol Ther. 1980 Aug;28(2):196-202 - PubMed
  19. Clin Pharmacol Ther. 1979 Jul;26(1):103-13 - PubMed
  20. N Engl J Med. 1975 Oct 2;293(14):702-5 - PubMed
  21. Ann Intern Med. 1976 Apr;84(4):420-5 - PubMed

Substances

MeSH terms

Publication Types

Grant support