Display options
Share it on

Arch Otorhinolaryngol. 1981;232(1):43-55. doi: 10.1007/BF00661002.

Ototoxicity or teratogenicity. An analysis of drug-induced effects on the early development of the mammalian otocyst.

Archives of oto-rhino-laryngology

M Anniko, H Nordemar

PMID: 7271577 DOI: 10.1007/BF00661002

Abstract

The 13th gestational day inner ear (otocyst stage) is particularly vulnerable to toxic influence from the environment during its further development. Ethacrynic acid in a concentration of 1 and 10 micrograms/ml caused complete arrest in development, and this was not overcome when withdrawing the drug after in vitro exposure to ethacrynic acid during 3 days. Gentamicin exposure at 1 and 10 micrograms/ml caused dysmorphogenesis but did not inhibit cytodifferentiation which, however, often was poor. Higher concentrations of gentamicin (100 micrograms/ml) had a more generalized toxic effect not only on epithelial but also on mesenchymal tissue.

References

  1. J Gen Physiol. 1969 Nov;54(5):650-63 - PubMed
  2. Except Child. 1967 Sep;34(1):5-12 - PubMed
  3. Arch Otolaryngol. 1964 Aug;80:136-40 - PubMed
  4. Acta Otolaryngol. 1979 Jan-Feb;87(1-2):72-8 - PubMed
  5. Acta Otolaryngol. 1971 Apr;71(4):303-12 - PubMed
  6. Ann Otol Rhinol Laryngol. 1976 Nov-Dec;85(6 Suppl 33 Pt 2):2-31 - PubMed
  7. Arch Otolaryngol. 1964 Oct;80:407-12 - PubMed
  8. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;79(2):204-8 - PubMed
  9. Acta Otolaryngol. 1961 May-Jun;53:413-23 - PubMed
  10. Laryngoscope. 1969 Sep;79(9):546-56 - PubMed
  11. J Clin Pathol. 1967 May;20(3):298-9 - PubMed
  12. Proc R Soc Med. 1965 Jul;58(7):493-7 - PubMed
  13. J Acoust Soc Am. 1976 Apr;59(4):940-4 - PubMed
  14. Nord Med. 1959 Oct 15;62:1512-4 - PubMed
  15. Trans Sect Otolaryngol Am Acad Ophthalmol Otolaryngol. 1976 May-Jun;82(3 Pt 1):273-80 - PubMed
  16. Biochem Pharmacol. 1968 Jul;17(7):1237-42 - PubMed
  17. Acta Otolaryngol. 1978 Jul-Aug;86(1-2):52-5 - PubMed
  18. Acta Otolaryngol. 1967;:Suppl 220:1-44 - PubMed
  19. Teratology. 1972 Jun;5(3):271-85 - PubMed
  20. Appl Microbiol. 1972 Mar;23(3):565-70 - PubMed
  21. Arch Otorhinolaryngol. 1979;224(3-4):285-99 - PubMed
  22. Ann Otol Rhinol Laryngol. 1974 Sep-Oct;83(5):613-8 - PubMed
  23. Arch Otorhinolaryngol. 1981;230(3):237-43 - PubMed
  24. Med Microbiol Immunol. 1975;161(1):23-39 - PubMed

Substances

MeSH terms

Publication Types