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Oliw E, Kövér G, Larsson C, et al. Indomethacin and diclofenac sodium increase sodium and water excretion after extracellular volume expansion in the rabbit. Eur J Pharmacol. 1978;49(4):381-8doi: 10.1016/0014-2999(78)90312-6.
Oliw, E., Kövér, G., Larsson, C., & Anggård, E. (1978). Indomethacin and diclofenac sodium increase sodium and water excretion after extracellular volume expansion in the rabbit. European journal of pharmacology, 49(4), 381-8. https://doi.org/10.1016/0014-2999(78)90312-6
Oliw, E, et al. "Indomethacin and diclofenac sodium increase sodium and water excretion after extracellular volume expansion in the rabbit." European journal of pharmacology vol. 49,4 (1978): 381-8. doi: https://doi.org/10.1016/0014-2999(78)90312-6
Oliw E, Kövér G, Larsson C, Anggård E. Indomethacin and diclofenac sodium increase sodium and water excretion after extracellular volume expansion in the rabbit. Eur J Pharmacol. 1978 Jun 15;49(4):381-8. doi: 10.1016/0014-2999(78)90312-6. PMID: 668809.
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Eur J Pharmacol. 1978 Jun 15;49(4):381-8. doi: 10.1016/0014-2999(78)90312-6.

Indomethacin and diclofenac sodium increase sodium and water excretion after extracellular volume expansion in the rabbit.

European journal of pharmacology

E Oliw, G Kövér, C Larsson, E Anggård

PMID: 668809 DOI: 10.1016/0014-2999(78)90312-6

Abstract

The renal effects of an acute extracellular fluid volume expansion (50 ml Ringer/kg body weight/60 min) were studied in aldosterone-treated (100 microgram/kg), anesthetized rabbits with and without pretreatment with either indomethacin (3.0 mg/kg) or diclofenac sodium (3.0 mg/kg), two different inhibitors of renal prostaglandin (PG) biosynthesis. In controls (n = 7), the volume expansion increased urine flow from 1.5 +/- 0.24 to 6.1 +/- 0.5 (S.E.) ml/min/100 g kidney weight and sodium excretion from 0.15 +/- 0.03 to 0.99 +/- 0.10 mmol/min/100 g. PAH and inulin clearance increased by 42 and 58%, respectively, while plasma renin activity and urinary excretion of PGF2 alpha-like immunoreactivity were reduced (P less than 0.05). In animals pretreated with indomethacin (n = 6) or diclofenac sodium (n = 6), the diuresis and the natriuresis following volume expansion were significantly increased about two-fold over controls, whereas PAH and inulin clearance, plasma renin activity and hematocrit did not differ from controls. Both drugs were found to reduce urinary excretion of PGF2 alpha-like immunoreactivity by 75--95% througout the experiment. The results indicate that diclofenac sodium, indomethacin and extracellular volume expansion enhance sodium and water excretion partly by suppression of a PG sensitive reabsorption process in the kidney.

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