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Beermann B, Groschinsky-Grind M. Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline. Eur J Clin Pharmacol. 1978;13(5):385-7doi: 10.1007/BF00644613.
Beermann, B., & Groschinsky-Grind, M. (1978). Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline. European journal of clinical pharmacology, 13(5), 385-7. https://doi.org/10.1007/BF00644613
Beermann, B, and Groschinsky-Grind, M. "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." European journal of clinical pharmacology vol. 13,5 (1978): 385-7. doi: https://doi.org/10.1007/BF00644613
Beermann B, Groschinsky-Grind M. Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline. Eur J Clin Pharmacol. 1978 Jul 30;13(5):385-7. doi: 10.1007/BF00644613. PMID: 668798.
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Eur J Clin Pharmacol. 1978 Jul 30;13(5):385-7. doi: 10.1007/BF00644613.

Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline.

European journal of clinical pharmacology

B Beermann, M Groschinsky-Grind

PMID: 668798 DOI: 10.1007/BF00644613

Abstract

Hydrochlorothiazide 75 mg was given twice p.o. to fasting subjects. In the second study they had been pretreated with propantheline 60 mg. Plasma and urine concentrations of hydrochlorothiazide were determined by GLC. Pretreatment with propantheline on average delayed the maximal plasma level of hct from 2.4 to 4.8 h (p less than 0.05); and the total urinary recovery of hydrochlorothiazide by 48 h was increased from 49.3 mg to 66.9 mg (p less than 0.005). It was concluded that propantheline increased substantially the absorption of the diuretic.

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