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Elfström J, Lindgren S. Influence of bed rest on the pharmacokinetics of phenazone. Eur J Clin Pharmacol. 1978;13(5):379-83doi: 10.1007/BF00644612.
Elfström, J., & Lindgren, S. (1978). Influence of bed rest on the pharmacokinetics of phenazone. European journal of clinical pharmacology, 13(5), 379-83. https://doi.org/10.1007/BF00644612
Elfström, J, and Lindgren, S. "Influence of bed rest on the pharmacokinetics of phenazone." European journal of clinical pharmacology vol. 13,5 (1978): 379-83. doi: https://doi.org/10.1007/BF00644612
Elfström J, Lindgren S. Influence of bed rest on the pharmacokinetics of phenazone. Eur J Clin Pharmacol. 1978 Jul 30;13(5):379-83. doi: 10.1007/BF00644612. PMID: 668797.
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Eur J Clin Pharmacol. 1978 Jul 30;13(5):379-83. doi: 10.1007/BF00644612.

Influence of bed rest on the pharmacokinetics of phenazone.

European journal of clinical pharmacology

J Elfström, S Lindgren

PMID: 668797 DOI: 10.1007/BF00644612

Abstract

The pharmacokinetics of a single dose of phenazone was studied in six objects while ambulant and during bed rest for 3 days. Elimination of the drug was followed for 12 h after oral and intravenous administration. The elimination rate constant and total body clearance were significantly increased during bed rest as compared to the ambulant period, but the differences were small. The apparent volume of distribution decreased significantly. No consistent change due to bed rest was found in the rate of absorption or bioavailability of the oral dose.

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