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Greenslade D, Havler ME, Humphrey MJ, et al. Biotransformation of tolmesoxide in animals and man. Xenobiotica. 1981;11(2):89-96doi: 10.3109/00498258109045278.
Greenslade, D., Havler, M. E., Humphrey, M. J., Jordan, B. J., Lewis, C. J., & Rance, M. J. (1981). Biotransformation of tolmesoxide in animals and man. Xenobiotica; the fate of foreign compounds in biological systems, 11(2), 89-96. https://doi.org/10.3109/00498258109045278
Greenslade, D, et al. "Biotransformation of tolmesoxide in animals and man." Xenobiotica; the fate of foreign compounds in biological systems vol. 11,2 (1981): 89-96. doi: https://doi.org/10.3109/00498258109045278
Greenslade D, Havler ME, Humphrey MJ, Jordan BJ, Lewis CJ, Rance MJ. Biotransformation of tolmesoxide in animals and man. Xenobiotica. 1981 Feb;11(2):89-96. doi: 10.3109/00498258109045278. PMID: 7233971.
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Xenobiotica. 1981 Feb;11(2):89-96. doi: 10.3109/00498258109045278.

Biotransformation of tolmesoxide in animals and man.

Xenobiotica; the fate of foreign compounds in biological systems

D Greenslade, M E Havler, M J Humphrey, B J Jordan, C J Lewis, M J Rance

PMID: 7233971 DOI: 10.3109/00498258109045278

Abstract

1. The excretion and metabolism of tolmesoxide ((4,5-dimethoxy-2-methylphenyl)-methylsulphoxide) has been studied in rat, dog and man. In all species, absorption of oral doses of [14C]tolmesoxide was virtually complete and 78--99% of the 14C was excreted in the urine. 2. In bile-duct cannulated rats, excretion in bile and urine was 49% and 53% dose respectively. Metabolites of tolmesoxide in bile undergo enterohepatic circulation with final elimination by the kidneys. 3. Quantification and identification of metabolites in urine (0-24 h) were obtained by two-dimensional t.l.c. Tolmesoxide was extensively metabolized in all animal species. 4. The major routes of metabolism in rat, dog and man were oxidation to sulphones and O-demethylation followed by sulphate or glucuronide conjugation. Little or none of the urinary 14C was present as sulphide derivatives.

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