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Kaymakcalan H, Dourdourekas D, Szanto PB, et al. Immunoglobulins in submassive hepatic necrosis. Am J Gastroenterol. 1978;69(3):289-94
Kaymakcalan, H., Dourdourekas, D., Szanto, P. B., Ainis, H., & Steigmann, F. (1978). Immunoglobulins in submassive hepatic necrosis. The American journal of gastroenterology, 69(3), 289-94.
Kaymakcalan, H, et al. "Immunoglobulins in submassive hepatic necrosis." The American journal of gastroenterology vol. 69,3 (1978): 289-94.
Kaymakcalan H, Dourdourekas D, Szanto PB, Ainis H, Steigmann F. Immunoglobulins in submassive hepatic necrosis. Am J Gastroenterol. 1978 Mar;69(3):289-94. PMID: 665646.
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Am J Gastroenterol. 1978 Mar;69(3):289-94.

Immunoglobulins in submassive hepatic necrosis.

The American journal of gastroenterology

H Kaymakcalan, D Dourdourekas, P B Szanto, H Ainis, F Steigmann

PMID: 665646

Abstract

The presence of submassive hepatic necrosis in acute liver injury of viral or toxic etiology in liver biopsy specimens is of great diagnostic and prognostic significance. Liver biopsy, however, cannot be performed in some of these patients due to an abnormal coagulation profile. Hence, other noninvasive methods for diagnosis of submassive hepatic necrosis would be helpful. We compared the serum immunoglobulin-G levels in 15 patients with typical acute viral hepatitis and 19 patients with severe acute viral hepatitis with submassive hepatic necrosis. The difference of the Ig-G levels in both groups was statistically significant. By using discriminant analysis we found that it was possible to make the correct diagnosis of submassive hepatic necrosis in 89.5% of patients with acute viral hepatitis when only Ig-G levels were utilized.

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