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Elsevier Science

Toxicol Lett. 1983 Apr;16(1):145-52. doi: 10.1016/0378-4274(83)90023-1.

Dose-dependent modification of 1,1-dichloroethylene toxicity by acetone.

Toxicology letters

W R Hewitt, G L Plaa

PMID: 6836608 DOI: 10.1016/0378-4274(83)90023-1

Abstract

The ability of acetone to potentiate the toxicity of 1,1-dichloroethylene (DCE) in male rats was investigated. A biphasic potentiation of DCE-induced hepatotoxicity was observed; low doses (5 and 10 mmol/kg, p.o.) of acetone were active, whereas higher doses (15 and 30 mmol/kg) were not. Nephrotoxicity was not affected.

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