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Jusko WJ, Schentag JJ, Clark JH, et al. Enhanced biotransformation of theophylline in marihuana and tobacco smokers. Clin Pharmacol Ther. 1978;24(4):405-10
Jusko, W. J., Schentag, J. J., Clark, J. H., Gardner, M., & Yurchak, A. M. (1978). Enhanced biotransformation of theophylline in marihuana and tobacco smokers. Clinical pharmacology and therapeutics, 24(4), 405-10.
Jusko, W J, et al. "Enhanced biotransformation of theophylline in marihuana and tobacco smokers." Clinical pharmacology and therapeutics vol. 24,4 (1978): 405-10.
Jusko WJ, Schentag JJ, Clark JH, Gardner M, Yurchak AM. Enhanced biotransformation of theophylline in marihuana and tobacco smokers. Clin Pharmacol Ther. 1978 Oct;24(4):405-10. PMID: 688731.
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Clin Pharmacol Ther. 1978 Oct;24(4):405-10.

Enhanced biotransformation of theophylline in marihuana and tobacco smokers.

Clinical pharmacology and therapeutics

W J Jusko, J J Schentag, J H Clark, M Gardner, A M Yurchak

PMID: 688731

Abstract

Single oral doses of theophylline were administered to 7 chronic marihuana smokers, to 7 chronic users of both marihuana and tobacco, and to 43 appropriate control subjects. Theophylline was cleared from the blood more rapidly in both marihuana and tobacco smokers with a mean increase in total clearance from 52 ml/kg/hr in nonsmokers to 74 ml/kg/hr in subjects who smoked either material alone. There was an additive increase in clearance to 93 ml/kg/hr in those who smoked both substances. Concern over enhanced metabolism of other drugs is probably warranted in tobacco and cannabis smokers.

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