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Monteleone P, Marano E, Steardo L. Evidence for a dose-dependent effect in the sex-specific plasma prolactin response to naloxone in humans. Boll Soc Ital Biol Sper. 1983;59(4):469-75
Monteleone, P., Marano, E., & Steardo, L. (1983). Evidence for a dose-dependent effect in the sex-specific plasma prolactin response to naloxone in humans. Bollettino della Societa italiana di biologia sperimentale, 59(4), 469-75.
Monteleone, P, et al. "Evidence for a dose-dependent effect in the sex-specific plasma prolactin response to naloxone in humans." Bollettino della Societa italiana di biologia sperimentale vol. 59,4 (1983): 469-75.
Monteleone P, Marano E, Steardo L. Evidence for a dose-dependent effect in the sex-specific plasma prolactin response to naloxone in humans. Boll Soc Ital Biol Sper. 1983 Apr 30;59(4):469-75. PMID: 6882542.
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Boll Soc Ital Biol Sper. 1983 Apr 30;59(4):469-75.

Evidence for a dose-dependent effect in the sex-specific plasma prolactin response to naloxone in humans.

Bollettino della Societa italiana di biologia sperimentale

P Monteleone, E Marano, L Steardo

PMID: 6882542

Abstract

In attempt to ascertain if the sex specific plasma PRL response to naloxone, that we suggested in previous studies, was a dose dependent effect, 26 healthy volunteers were studied. They received naloxone 2 mg and 4.8 mg or a volume matched of saline i.v. as a bolus. Blood samples were collected and plasma PRL was measured by double antibody RIA. Naloxone, at dose of 2 mg, was able to decrease significantly plasma PRL levels in normally menstruating women (p less than 0.05 at 60 min.; p less than 0.01 at 120 min.), but not in post-menopausal ones and in men. In addition, the dose of 4.8 mg of the drug did not change plasma PRL in any group. These results suggest a dose-dependent effect in the sex specific PRL response to naloxone in humans.

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