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Dal Bo L, Marcucci F, Mussini E, et al. Plasma levels of chlorodesmethyldiazepam in humans. Biopharm Drug Dispos. 1980;1(3):123-6doi: 10.1002/bdd.2510010306.
Dal Bo, L., Marcucci, F., Mussini, E., Perbellini, D., Castellani, A., & Fresia, P. (1980). Plasma levels of chlorodesmethyldiazepam in humans. Biopharmaceutics & drug disposition, 1(3), 123-6. https://doi.org/10.1002/bdd.2510010306
Dal Bo, L, et al. "Plasma levels of chlorodesmethyldiazepam in humans." Biopharmaceutics & drug disposition vol. 1,3 (1980): 123-6. doi: https://doi.org/10.1002/bdd.2510010306
Dal Bo L, Marcucci F, Mussini E, Perbellini D, Castellani A, Fresia P. Plasma levels of chlorodesmethyldiazepam in humans. Biopharm Drug Dispos. 1980 Jan-Mar;1(3):123-6. doi: 10.1002/bdd.2510010306. PMID: 6778522.
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Biopharm Drug Dispos. 1980 Jan-Mar;1(3):123-6. doi: 10.1002/bdd.2510010306.

Plasma levels of chlorodesmethyldiazepam in humans.

Biopharmaceutics & drug disposition

L Dal Bo, F Marcucci, E Mussini, D Perbellini, A Castellani, P Fresia

PMID: 6778522 DOI: 10.1002/bdd.2510010306

Abstract

Chlorodesmethyldiazepam (I) concentrations were followed for 72 h in the plasma of four volunteers given 2 mg of the drug orally. The drug appears to be well absorbed, reaching peak plasma levels of 20--30 ng ml-1 1--2 h after administration; 72 h after administration, plasma concentrations are still measurable (5 ng ml-1). The analytical method involved a single extraction of I from the plasma into benzene followed by centrifugation, evaporation, and gas-chromatographic analysis of the samples.

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