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Kurtz AB, Capper SJ, Clifford J, et al. The effect of fenclofenac on thyroid function. Clin Endocrinol (Oxf). 1981;15(2):117-24doi: 10.1111/j.1365-2265.1981.tb00645.x.
Kurtz, A. B., Capper, S. J., Clifford, J., Humphrey, M. J., & Lukinac, L. (1981). The effect of fenclofenac on thyroid function. Clinical endocrinology, 15(2), 117-24. https://doi.org/10.1111/j.1365-2265.1981.tb00645.x
Kurtz, A B, et al. "The effect of fenclofenac on thyroid function." Clinical endocrinology vol. 15,2 (1981): 117-24. doi: https://doi.org/10.1111/j.1365-2265.1981.tb00645.x
Kurtz AB, Capper SJ, Clifford J, Humphrey MJ, Lukinac L. The effect of fenclofenac on thyroid function. Clin Endocrinol (Oxf). 1981 Aug;15(2):117-24. doi: 10.1111/j.1365-2265.1981.tb00645.x. PMID: 6796298.
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Clin Endocrinol (Oxf). 1981 Aug;15(2):117-24. doi: 10.1111/j.1365-2265.1981.tb00645.x.

The effect of fenclofenac on thyroid function.

Clinical endocrinology

A B Kurtz, S J Capper, J Clifford, M J Humphrey, L Lukinac

PMID: 6796298 DOI: 10.1111/j.1365-2265.1981.tb00645.x

Abstract

The non-steroidal anti-inflammatory agent fenclofenac competitively inhibits the binding of thyroxine(T4) and triiodothyronine (T3) by thyroxine-binding globulin(TBG). Eight male volunteers completed a 4-week study during which they took fenclofenac 600 mg twice daily. The concentration of fenclofenac in serum reached a plateau after 1 week of therapy after which the mean concentration(+/SEM) of the drug in serum was 78.6 o.2 mg/1. During the steady state period on treatment there were reductions of the mean serum concentrations of total T4 to 35% (P less than 0.001), total T3 to 55% (P less than 0.001), free T4 to 69% (P less than 0.001) and free T3 to 90% (NS) of the respective pretreatment values. There were also significant changes in the concentrations of thyrotropin and reverse T3 in serum. After starting treatment with fenclofenac serum concentrations of thyrotrophin fell to a nadir after 2-4 days at which time the mean concentration was 34% (P less than 0.01) of the pretreatment value, whilst reverse T3 values increased to a maximum of 136% (P less than 0.001) of the pretreatment values over 1-2 days. There was subsequently an increase of the thyrotrophin and a reduction in reverse T3 concentrations to normal by 2 weeks of pretreatment. Transient pituitary suppression was also suggested by the response to to thryotrophin-releasing hormone (TRH): 7 days after starting fenclofenac the mean thyrotrophin response was 62% (P less than 9.001) of the pretreatment value. After 4 weeks of fenclofenac the response of TRH had returned to normal. After discontinuing fenclofenac there was a transient increase in the mean concentration of thyrotrophin in serum, to 129% of the pretreatment value (P less than 0.001), with a subsequent return to normal. Four weeks after discontinuing fenclofenac the serum concentrations of thyroid hormones and thyrotrophin were normal.

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