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Bittencourt PR, Wade P, Smith AT, et al. The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration. Br J Clin Pharmacol. 1981;12(4):523-33doi: 10.1111/j.1365-2125.1981.tb01261.x.
Bittencourt, P. R., Wade, P., Smith, A. T., & Richens, A. (1981). The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration. British journal of clinical pharmacology, 12(4), 523-33. https://doi.org/10.1111/j.1365-2125.1981.tb01261.x
Bittencourt, P R, et al. "The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration." British journal of clinical pharmacology vol. 12,4 (1981): 523-33. doi: https://doi.org/10.1111/j.1365-2125.1981.tb01261.x
Bittencourt PR, Wade P, Smith AT, Richens A. The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration. Br J Clin Pharmacol. 1981 Oct;12(4):523-33. doi: 10.1111/j.1365-2125.1981.tb01261.x. PMID: 6794587; PMCID: PMC1401908.
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Br J Clin Pharmacol. 1981 Oct;12(4):523-33. doi: 10.1111/j.1365-2125.1981.tb01261.x.

The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.

British journal of clinical pharmacology

P R Bittencourt, P Wade, A T Smith, A Richens

PMID: 6794587 PMCID: PMC1401908 DOI: 10.1111/j.1365-2125.1981.tb01261.x
Free PMC Article

Abstract

1 Six healthy male volunteers received single oral doses of 10 mg diazepam, 20 mg temazepam, 15 mg flurazepam, 5 mg nitrazepam, 10 mg desmethyl-diazepam and placebo in a double-blind randomized fashion. 2 Peak velocity of saccadic eye movements, serum benzodiazepine concentration, and subjective ratings of wakefulness and co-ordination were measured at intervals up to 12 h after drug administration. 3 All active treatments produced a statistically significant decrease in peak saccadic velocity. The effect of temazepam and diazepam was generally more pronounced than that of flurazepam, nitrazepam and desmethyl-diazepam. 4 There were log-linear correlations between peak saccadic velocity and serum benzodiazepine concentration after ingestion of temazepam, diazepam and nitrazepam. 5 These results demonstrate a clear relationship between serum benzodiazepine concentration and its effect on a convenient measure of brainstem reticular formation function.

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