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O'Boyle CP, Laher M, O'Brien ET, et al. The clinical pharmacology of tolmesoxide. A new vasodilator antihypertensive agent. Eur J Clin Pharmacol. 1982;23(2):93-7doi: 10.1007/BF00545961.
O'Boyle, C. P., Laher, M., O'Brien, E. T., O'Malley, K., & Kelly, J. G. (1982). The clinical pharmacology of tolmesoxide. A new vasodilator antihypertensive agent. European journal of clinical pharmacology, 23(2), 93-7. https://doi.org/10.1007/BF00545961
O'Boyle, C P, et al. "The clinical pharmacology of tolmesoxide. A new vasodilator antihypertensive agent." European journal of clinical pharmacology vol. 23,2 (1982): 93-7. doi: https://doi.org/10.1007/BF00545961
O'Boyle CP, Laher M, O'Brien ET, O'Malley K, Kelly JG. The clinical pharmacology of tolmesoxide. A new vasodilator antihypertensive agent. Eur J Clin Pharmacol. 1982;23(2):93-7. doi: 10.1007/BF00545961. PMID: 6754385.
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Eur J Clin Pharmacol. 1982;23(2):93-7. doi: 10.1007/BF00545961.

The clinical pharmacology of tolmesoxide. A new vasodilator antihypertensive agent.

European journal of clinical pharmacology

C P O'Boyle, M Laher, E T O'Brien, K O'Malley, J G Kelly

PMID: 6754385 DOI: 10.1007/BF00545961

Abstract

The haemodynamic response and pharmacokinetics of single dose oral tolmesoxide were studied at various dose levels in 4 patients with severe hypertension. There was a reproducible fall in mean arterial pressure from baseline of 24.2% and a rise in heart rate of 37.6% following administration of tolmesoxide. The onset of antihypertensive action occurred within 1 h, with a peak effect at 3 h after dosing. The mean duration of action was up to 12.0 h. Tolmesoxide had a mean half-life of 3.0 h. It was rapidly absorbed with a mean peak plasma level occurring at 1.0 h. Plasma levels correlated well with the doses administered. Side-effects include mild nausea, facial flushing and postural symptoms.

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